[Autoimmune haemolytic anaemia: a review and report of four cases]. / Az autoimmun haemolyticus anaemiáról négy eset kapcsán.
Orv Hetil
; 156(11): 449-56, 2015 Mar.
Article
in Hu
| MEDLINE
| ID: mdl-25749539
ABSTRACT
Treatment of autoimmune haemolytic anaemia is still a challenge to clinicians. Even today it may be lethal. Half of the cases are secondary due to an underlying disease, and the others are primary or idiopathic cases. According to the specificity and type of autoantibodies there are warm and cold type forms of autoimmune haemolytic anaemia. The hallmark of the diagnosis is to detect the presence of haemolysis by clinical and laboratory signs and detect the underlying autoantibodies. Treatment of autoimmune haemolytic anaemia is still a challenge to clinicians. We still loose patients due to excessive haemolysis or severe infections caused by immunosuppression. First line treatment is corticosteroids. Other immunosuppressive agents like cyclophosphamide, azathioprine, cyclosporine or the off label rituximab can be used in case of corticosteroid refractoriness. Splenectomy is a considerable option in selective cases. The authors discuss treatment options and highlight difficulties by presenting 4 cases.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Autoantibodies
/
Hemoglobins
/
Adrenal Cortex Hormones
/
Immunosuppressive Agents
/
Anemia, Hemolytic, Autoimmune
Limits:
Aged
/
Female
/
Humans
/
Male
Language:
Hu
Journal:
Orv Hetil
Year:
2015
Type:
Article