The effects of exendin-4 treatment on graft failure: an animal study using a novel re-vascularized minimal human islet transplant model.

Sahraoui, Afaf; Winzell, Maria Sörhede; Gorman, Tracy; Smith, Dave M; Skrtic, Stanko; Hoeyem, Merete; Abadpour, Shadab; Johansson, Lars; Korsgren, Olle; Foss, Aksel; Scholz, Hanne

Sahraoui, Afaf; Winzell, Maria Sörhede; Gorman, Tracy; Smith, Dave M; Skrtic, Stanko; Hoeyem, Merete; Abadpour, Shadab; Johansson, Lars; Korsgren, Olle; Foss, Aksel; Scholz, Hanne.

Affiliation

Sahraoui A; Institute for Surgical Research and Section for Transplantation Surgery, Oslo University Hospital, Oslo, Norway.
Winzell MS; AstraZeneca R&D, Mölndal, Sweden.
Gorman T; AstraZeneca, Alderley Park, Cheshire, United Kingdom.
Smith DM; AstraZeneca R&D, Mölndal, Sweden.
Skrtic S; AstraZeneca R&D, Mölndal, Sweden.
Hoeyem M; Institute for Surgical Research and Section for Transplantation Surgery, Oslo University Hospital, Oslo, Norway.
Abadpour S; Institute for Surgical Research and Section for Transplantation Surgery, Oslo University Hospital, Oslo, Norway.
Johansson L; Department of Radiology, Oncology and Radiation Sciences, Uppsala University Hospital, Uppsala, Sweden.
Korsgren O; Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
Foss A; Institute for Surgical Research and Section for Transplantation Surgery, Oslo University Hospital, Oslo, Norway; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Scholz H; Institute for Surgical Research and Section for Transplantation Surgery, Oslo University Hospital, Oslo, Norway.

PLoS One ; 10(3): e0121204, 2015.

Article in En | MEDLINE | ID: mdl-25793295

Subject(s)

Graft Survival/drug effects; Islets of Langerhans Transplantation; Islets of Langerhans/blood supply; Peptides/pharmacology; Venoms/pharmacology; Animals; Apoptosis/drug effects; Blood Glucose/metabolism; C-Peptide/metabolism; Cell Count; Diabetes Mellitus, Experimental/blood; Diabetes Mellitus, Experimental/complications; Diabetes Mellitus, Experimental/therapy; Exenatide; Fasting/blood; Glucagon/metabolism; Glucagon-Like Peptide 1/metabolism; Glucose Tolerance Test; Humans; Hyperglycemia/blood; Hyperglycemia/complications; Hyperglycemia/drug therapy; Insulin/metabolism; Insulin Secretion; Insulin-Secreting Cells/drug effects; Insulin-Secreting Cells/pathology; Islets of Langerhans/drug effects; Male; Mice, Inbred BALB C; Models, Animal; Peptides/administration & dosage; Peptides/therapeutic use; Venoms/administration & dosage; Venoms/therapeutic use

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Peptides / Venoms / Islets of Langerhans Transplantation / Islets of Langerhans / Graft Survival Type of study: Prognostic_studies Limits: Animals / Humans / Male Language: En Journal: PLoS One Journal subject: CIENCIA / MEDICINA Year: 2015 Type: Article Affiliation country: Norway

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