Anti-ictogenic and antiepileptogenic properties of brivaracetam in mature and immature rats.

Dupuis, Nina; Matagne, Alain; Staelens, Ludovicus; Dournaud, Pascal; Desnous, Béatrice; Gressens, Pierre; Auvin, Stéphane

Dupuis, Nina; Matagne, Alain; Staelens, Ludovicus; Dournaud, Pascal; Desnous, Béatrice; Gressens, Pierre; Auvin, Stéphane.

Affiliation

Dupuis N; Inserm, U1141, Paris, France.
Matagne A; University Paris Diderot, Sorbonne Paris Cité, INSERM UMR1141, Paris, France.
Staelens L; Non-Clinical Development, UCB Pharma, Braine-l'Alleud, Belgium.
Dournaud P; Non-Clinical Development, UCB Pharma, Braine-l'Alleud, Belgium.
Desnous B; Inserm, U1141, Paris, France.
Gressens P; University Paris Diderot, Sorbonne Paris Cité, INSERM UMR1141, Paris, France.
Auvin S; Inserm, U1141, Paris, France.

Epilepsia ; 56(5): 800-5, 2015 May.

Article in En | MEDLINE | ID: mdl-25818358

Subject(s)

Anticonvulsants/therapeutic use; Epilepsy/drug therapy; Pyrrolidinones/therapeutic use; Age Factors; Analysis of Variance; Animals; Animals, Newborn; Anticonvulsants/metabolism; Disease Models, Animal; Dose-Response Relationship, Drug; Electric Stimulation/adverse effects; Electroencephalography; Epilepsy/etiology; Epilepsy/metabolism; Epilepsy/pathology; Hippocampus/drug effects; Hippocampus/physiopathology; Kindling, Neurologic/drug effects; Kindling, Neurologic/physiology; Male; Pyrrolidinones/metabolism; Rats; Rats, Wistar

Key words

Antiepileptic drugs; Brivaracetam; Epileptogenesis; Kindling; Rat

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrrolidinones / Epilepsy / Anticonvulsants Type of study: Etiology_studies / Prognostic_studies Limits: Animals Language: En Journal: Epilepsia Year: 2015 Type: Article Affiliation country: France

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