Hypomethylation and up-regulation of PD-1 in T cells by azacytidine in MDS/AML patients: A rationale for combined targeting of PD-1 and DNA methylation.

Ørskov, Andreas D; Treppendahl, Marianne B; Skovbo, Anni; Holm, Mette S; Friis, Lone S; Hokland, Marianne; Grønbæk, Kirsten

Ørskov, Andreas D; Treppendahl, Marianne B; Skovbo, Anni; Holm, Mette S; Friis, Lone S; Hokland, Marianne; Grønbæk, Kirsten.

Affiliation

Ørskov AD; Department of Hematology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
Treppendahl MB; Department of Hematology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
Skovbo A; Department of Biomedicine, Aarhus University, Aarhus, Denmark.
Holm MS; FACS Core Facility, Aarhus University, Aarhus, Denmark.
Friis LS; Department of Hematology, Aarhus University Hospital, Aarhus, Denmark.
Hokland M; Department of Hematology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
Grønbæk K; Department of Hematology, Odense University Hospital, Odense, Denmark.

Oncotarget ; 6(11): 9612-26, 2015 Apr 20.

Article in En | MEDLINE | ID: mdl-25823822

Subject(s)

Antimetabolites/pharmacology; Azacitidine/pharmacology; DNA Methylation/drug effects; Myelodysplastic Syndromes/drug therapy; Programmed Cell Death 1 Receptor/genetics; Promoter Regions, Genetic/genetics; T-Lymphocyte Subsets/metabolism; Aged; Aged, 80 and over; Blood Cells/drug effects; Blood Cells/metabolism; Drug Resistance; Female; Gene Expression Regulation/drug effects; Humans; Leukemia, Myeloid, Acute/drug therapy; Leukemia, Myeloid, Acute/genetics; Leukemia, Myeloid, Acute/metabolism; Leukemia, Myelomonocytic, Chronic/drug therapy; Leukemia, Myelomonocytic, Chronic/genetics; Leukemia, Myelomonocytic, Chronic/metabolism; Lymphocyte Activation; Male; Middle Aged; Myelodysplastic Syndromes/genetics; Myelodysplastic Syndromes/metabolism; Neoplasm Proteins/biosynthesis; Neoplasm Proteins/genetics; Neoplasm Proteins/physiology; Programmed Cell Death 1 Receptor/biosynthesis; Programmed Cell Death 1 Receptor/physiology; Promoter Regions, Genetic/drug effects; RNA, Messenger/biosynthesis; RNA, Messenger/genetics; RNA, Neoplasm/biosynthesis; RNA, Neoplasm/genetics; T-Lymphocyte Subsets/drug effects

Key words

DNA methylation; T cells; hypomethylating agents; myelodysplastic syndromes; programmed death-1

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Azacitidine / Myelodysplastic Syndromes / T-Lymphocyte Subsets / Promoter Regions, Genetic / DNA Methylation / Programmed Cell Death 1 Receptor / Antimetabolites Limits: Aged / Aged80 / Female / Humans / Male / Middle aged Language: En Journal: Oncotarget Year: 2015 Type: Article Affiliation country: Denmark

Fulltext

XML

PubMed Links

Search on Google