ATP4a is required for development and function of the Xenopus mucociliary epidermis - a potential model to study proton pump inhibitor-associated pneumonia.

Walentek, Peter; Beyer, Tina; Hagenlocher, Cathrin; Müller, Christina; Feistel, Kerstin; Schweickert, Axel; Harland, Richard M; Blum, Martin

Walentek, Peter; Beyer, Tina; Hagenlocher, Cathrin; Müller, Christina; Feistel, Kerstin; Schweickert, Axel; Harland, Richard M; Blum, Martin.

Affiliation

Walentek P; Institute of Zoology, University of Hohenheim, Garbenstrasse 30, 70593 Stuttgart, Germany; Department of Molecular and Cell Biology, Center for Integrative Genomics, University of California at Berkeley, Berkeley, CA 94720, USA. Electronic address: walentek@berkeley.edu.
Beyer T; Institute of Zoology, University of Hohenheim, Garbenstrasse 30, 70593 Stuttgart, Germany.
Hagenlocher C; Institute of Zoology, University of Hohenheim, Garbenstrasse 30, 70593 Stuttgart, Germany.
Müller C; Institute of Zoology, University of Hohenheim, Garbenstrasse 30, 70593 Stuttgart, Germany.
Feistel K; Institute of Zoology, University of Hohenheim, Garbenstrasse 30, 70593 Stuttgart, Germany.
Schweickert A; Institute of Zoology, University of Hohenheim, Garbenstrasse 30, 70593 Stuttgart, Germany.
Harland RM; Department of Molecular and Cell Biology, Center for Integrative Genomics, University of California at Berkeley, Berkeley, CA 94720, USA.
Blum M; Institute of Zoology, University of Hohenheim, Garbenstrasse 30, 70593 Stuttgart, Germany.

Dev Biol ; 408(2): 292-304, 2015 Dec 15.

Article in En | MEDLINE | ID: mdl-25848696

Subject(s)

Cross Infection/etiology; H(+)-K(+)-Exchanging ATPase/metabolism; Mucociliary Clearance/drug effects; Pneumonia/etiology; Proton Pump Inhibitors/adverse effects; Xenopus Proteins/antagonists & inhibitors; Xenopus Proteins/metabolism; Xenopus laevis/embryology; Xenopus laevis/metabolism; Animals; Animals, Genetically Modified; Cross Infection/physiopathology; Disease Models, Animal; Forkhead Transcription Factors/genetics; Forkhead Transcription Factors/metabolism; Gene Knockdown Techniques; H(+)-K(+)-Exchanging ATPase/genetics; Humans; Mucociliary Clearance/physiology; Pneumonia/physiopathology; Respiratory Mucosa/drug effects; Respiratory Mucosa/embryology; Respiratory Mucosa/physiopathology; Wnt Signaling Pathway; Xenopus Proteins/genetics; Xenopus laevis/genetics

Key words

ATP4; Cilia; Proton pump inhibitor; Small secretory cells; Wnt; Xenopus laevis

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pneumonia / Xenopus laevis / Mucociliary Clearance / Cross Infection / H(/)-K(/)-Exchanging ATPase / Xenopus Proteins / Proton Pump Inhibitors Type of study: Prognostic_studies / Risk_factors_studies Limits: Animals / Humans Language: En Journal: Dev Biol Year: 2015 Type: Article

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