ß,γ-Bis-substituted PNA with configurational and conformational switch: preferred binding to cDNA/RNA and cell-uptake studies.
Chem Commun (Camb)
; 51(36): 7693-6, 2015 May 04.
Article
in En
| MEDLINE
| ID: mdl-25848728
ABSTRACT
(S,S)- and (R,R)-ß,γ-Bis-substituted PNAs were synthesized from the C-2 symmetric vicinal diamine system embedded in 1,4 dihydroxybutane and 1,4-dimethoxybutane scaffolds. (R,R)-ß,γ-Bis-methoxymethyl-PNA derived from d-tartaric acid was found to be in the right configuration and conformation to be an excellent mimic of PNA, endowed with superior ability to enter into cells.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
RNA
/
Cells
/
DNA, Complementary
/
Peptide Nucleic Acids
Limits:
Humans
Language:
En
Journal:
Chem Commun (Camb)
Journal subject:
QUIMICA
Year:
2015
Type:
Article
Affiliation country:
India