High EMT Signature Score of Invasive Non-Small Cell Lung Cancer (NSCLC) Cells Correlates with NF&#954;B Driven Colony-Stimulating Factor 2 (CSF2/GM-CSF) Secretion by Neighboring Stromal Fibroblasts.

Rudisch, Albin; Dewhurst, Matthew Richard; Horga, Luminita Gabriela; Kramer, Nina; Harrer, Nathalie; Dong, Meng; van der Kuip, Heiko; Wernitznig, Andreas; Bernthaler, Andreas; Dolznig, Helmut; Sommergruber, Wolfgang

High EMT Signature Score of Invasive Non-Small Cell Lung Cancer (NSCLC) Cells Correlates with NFκB Driven Colony-Stimulating Factor 2 (CSF2/GM-CSF) Secretion by Neighboring Stromal Fibroblasts.

Rudisch, Albin; Dewhurst, Matthew Richard; Horga, Luminita Gabriela; Kramer, Nina; Harrer, Nathalie; Dong, Meng; van der Kuip, Heiko; Wernitznig, Andreas; Bernthaler, Andreas; Dolznig, Helmut; Sommergruber, Wolfgang.

Affiliation

Rudisch A; Department of Lead Discovery, Boehringer Ingelheim RCV GmbH & Co KG, Vienna, Austria; Department of Microbiology, Immunobiology and Genetics, Center of Molecular Biology, Max F. Perutz Laboratories, University of Vienna, Vienna, Austria.
Dewhurst MR; Department of Lead Discovery, Boehringer Ingelheim RCV GmbH & Co KG, Vienna, Austria.
Horga LG; Department of Lead Discovery, Boehringer Ingelheim RCV GmbH & Co KG, Vienna, Austria.
Kramer N; Institute of Medical Genetics, Medical University of Vienna, Vienna, Austria.
Harrer N; Department of Lead Discovery, Boehringer Ingelheim RCV GmbH & Co KG, Vienna, Austria.
Dong M; Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology and University of Tübingen, Stuttgart, Baden-Württemberg, Germany.
van der Kuip H; Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology and University of Tübingen, Stuttgart, Baden-Württemberg, Germany.
Wernitznig A; Department of Lead Discovery, Boehringer Ingelheim RCV GmbH & Co KG, Vienna, Austria.
Bernthaler A; Department of Lead Discovery, Boehringer Ingelheim RCV GmbH & Co KG, Vienna, Austria.
Dolznig H; Institute of Medical Genetics, Medical University of Vienna, Vienna, Austria.
Sommergruber W; Department of Lead Discovery, Boehringer Ingelheim RCV GmbH & Co KG, Vienna, Austria.

PLoS One ; 10(4): e0124283, 2015.

Article in En | MEDLINE | ID: mdl-25919140

Subject(s)

Carcinoma, Non-Small-Cell Lung/metabolism; Carcinoma, Non-Small-Cell Lung/pathology; Epithelial-Mesenchymal Transition/genetics; Fibroblasts/metabolism; Granulocyte-Macrophage Colony-Stimulating Factor/metabolism; Lung Neoplasms/pathology; NF-kappa B/metabolism; Animals; Cadherins/metabolism; Carcinoma, Non-Small-Cell Lung/genetics; Cell Communication/drug effects; Cell Line, Tumor; Cytokines/metabolism; Dermis/pathology; Epithelial-Mesenchymal Transition/drug effects; Fibroblasts/drug effects; Gene Expression Profiling; Gene Expression Regulation, Neoplastic/drug effects; Gene Regulatory Networks/drug effects; Genes, Reporter; Hepatocyte Growth Factor/pharmacology; Humans; Inflammation/pathology; Kruppel-Like Factor 4; Lung Neoplasms/genetics; Lung Neoplasms/metabolism; Neoplasm Invasiveness; Phenotype; Proto-Oncogene Proteins c-met/metabolism; RNA, Messenger/genetics; RNA, Messenger/metabolism; Rats; Signal Transduction/drug effects; Signal Transduction/genetics; Spheroids, Cellular/drug effects; Spheroids, Cellular/metabolism; Spheroids, Cellular/pathology; Stromal Cells/metabolism; Up-Regulation/drug effects; Up-Regulation/genetics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Granulocyte-Macrophage Colony-Stimulating Factor / NF-kappa B / Carcinoma, Non-Small-Cell Lung / Epithelial-Mesenchymal Transition / Fibroblasts / Lung Neoplasms Type of study: Prognostic_studies Language: En Journal: PLoS One Journal subject: CIENCIA / MEDICINA Year: 2015 Type: Article Affiliation country: Austria

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