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Functionally defined therapeutic targets in diffuse intrinsic pontine glioma.
Grasso, Catherine S; Tang, Yujie; Truffaux, Nathalene; Berlow, Noah E; Liu, Lining; Debily, Marie-Anne; Quist, Michael J; Davis, Lara E; Huang, Elaine C; Woo, Pamelyn J; Ponnuswami, Anitha; Chen, Spenser; Johung, Tessa B; Sun, Wenchao; Kogiso, Mari; Du, Yuchen; Qi, Lin; Huang, Yulun; Hütt-Cabezas, Marianne; Warren, Katherine E; Le Dret, Ludivine; Meltzer, Paul S; Mao, Hua; Quezado, Martha; van Vuurden, Dannis G; Abraham, Jinu; Fouladi, Maryam; Svalina, Matthew N; Wang, Nicholas; Hawkins, Cynthia; Nazarian, Javad; Alonso, Marta M; Raabe, Eric H; Hulleman, Esther; Spellman, Paul T; Li, Xiao-Nan; Keller, Charles; Pal, Ranadip; Grill, Jacques; Monje, Michelle.
Affiliation
  • Grasso CS; Center for Spatial Systems Biomedicine, Department of Molecular and Medical Genetics, Oregon Health &Science University (OHSU), Portland, Oregon, USA.
  • Tang Y; 1] Department of Neurology, Stanford University, Stanford, California, USA. [2] Department of Neurosurgery, Stanford University, Stanford, California, USA. [3] Department of Pediatrics, Stanford University, Stanford, California, USA. [4] Department of Pathology, Stanford University, Stanford, Califo
  • Truffaux N; CNRS, UMR 8203, Gustave Roussy, Université Paris-Sud, Villejuif, France.
  • Berlow NE; Electrical and Computer Engineering, Texas Tech University, Lubbock, Texas, USA.
  • Liu L; 1] Department of Neurology, Stanford University, Stanford, California, USA. [2] Department of Neurosurgery, Stanford University, Stanford, California, USA. [3] Department of Pediatrics, Stanford University, Stanford, California, USA. [4] Department of Pathology, Stanford University, Stanford, Califo
  • Debily MA; 1] CNRS, UMR 8203, Gustave Roussy, Université Paris-Sud, Villejuif, France. [2] Département de biologie, Université d'Evry-Val d'Essone, Evry, France.
  • Quist MJ; Center for Spatial Systems Biomedicine, Department of Molecular and Medical Genetics, Oregon Health &Science University (OHSU), Portland, Oregon, USA.
  • Davis LE; Pediatric Cancer Biology Program, Papé Family Pediatric Research Institute, Department of Pediatrics, OHSU, Portland, Oregon, USA.
  • Huang EC; Pediatric Cancer Biology Program, Papé Family Pediatric Research Institute, Department of Pediatrics, OHSU, Portland, Oregon, USA.
  • Woo PJ; 1] Department of Neurology, Stanford University, Stanford, California, USA. [2] Department of Neurosurgery, Stanford University, Stanford, California, USA. [3] Department of Pediatrics, Stanford University, Stanford, California, USA. [4] Department of Pathology, Stanford University, Stanford, Califo
  • Ponnuswami A; 1] Department of Neurology, Stanford University, Stanford, California, USA. [2] Department of Neurosurgery, Stanford University, Stanford, California, USA. [3] Department of Pediatrics, Stanford University, Stanford, California, USA. [4] Department of Pathology, Stanford University, Stanford, Califo
  • Chen S; 1] Department of Neurology, Stanford University, Stanford, California, USA. [2] Department of Neurosurgery, Stanford University, Stanford, California, USA. [3] Department of Pediatrics, Stanford University, Stanford, California, USA. [4] Department of Pathology, Stanford University, Stanford, Califo
  • Johung TB; 1] Department of Neurology, Stanford University, Stanford, California, USA. [2] Department of Neurosurgery, Stanford University, Stanford, California, USA. [3] Department of Pediatrics, Stanford University, Stanford, California, USA. [4] Department of Pathology, Stanford University, Stanford, Califo
  • Sun W; Department of Neurology, Stanford University, Stanford, California, USA.
  • Kogiso M; Laboratory of Molecular Neurooncology, Texas Children's Cancer Center, Baylor College of Medicine, Houston, Texas, USA.
  • Du Y; Laboratory of Molecular Neurooncology, Texas Children's Cancer Center, Baylor College of Medicine, Houston, Texas, USA.
  • Qi L; Laboratory of Molecular Neurooncology, Texas Children's Cancer Center, Baylor College of Medicine, Houston, Texas, USA.
  • Huang Y; 1] Laboratory of Molecular Neurooncology, Texas Children's Cancer Center, Baylor College of Medicine, Houston, Texas, USA. [2] Present addresses: Key Laboratory of Cell Differentiation and Apoptosis of National Ministry of Education, Department of Pathophysiology, Shanghai Jiao Tong University Schoo
  • Hütt-Cabezas M; 1] Department of Oncology, Johns Hopkins University, Baltimore, Maryland, USA. [2] Department of Pathology, Johns Hopkins University, Baltimore, Maryland, USA.
  • Warren KE; National Cancer Institute, Bethesda, Maryland, USA.
  • Le Dret L; CNRS, UMR 8203, Gustave Roussy, Université Paris-Sud, Villejuif, France.
  • Meltzer PS; National Cancer Institute, Bethesda, Maryland, USA.
  • Mao H; Laboratory of Molecular Neurooncology, Texas Children's Cancer Center, Baylor College of Medicine, Houston, Texas, USA.
  • Quezado M; National Cancer Institute, Bethesda, Maryland, USA.
  • van Vuurden DG; 1] Department of Pediatric Oncology and Hematology, VU University Medical Center, Amsterdam, The Netherlands. [2] Neuro-Oncology Research Group Cancer Center Amsterdam, VU University Medical Center, Amsterdam, The Netherlands.
  • Abraham J; Pediatric Cancer Biology Program, Papé Family Pediatric Research Institute, Department of Pediatrics, OHSU, Portland, Oregon, USA.
  • Fouladi M; Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
  • Svalina MN; 1] Center for Spatial Systems Biomedicine, Department of Molecular and Medical Genetics, Oregon Health &Science University (OHSU), Portland, Oregon, USA. [2] Children's Cancer Therapy Development Institute, Fort Collins, Colorado, USA.
  • Wang N; Center for Spatial Systems Biomedicine, Department of Molecular and Medical Genetics, Oregon Health &Science University (OHSU), Portland, Oregon, USA.
  • Hawkins C; 1] Department of Pediatric Laboratory Medicine, University of Toronto, Toronto, Ontario, Canada. [2] Labatt Brain Tumor Research Centre, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
  • Nazarian J; Center for Research Institute, Children's National Health Systems, Washington, DC, USA.
  • Alonso MM; Department of Oncology, University Hospital of Navarra, Pamplona, Spain.
  • Raabe EH; 1] Department of Oncology, Johns Hopkins University, Baltimore, Maryland, USA. [2] Department of Pathology, Johns Hopkins University, Baltimore, Maryland, USA.
  • Hulleman E; 1] Department of Pediatric Oncology and Hematology, VU University Medical Center, Amsterdam, The Netherlands. [2] Neuro-Oncology Research Group Cancer Center Amsterdam, VU University Medical Center, Amsterdam, The Netherlands.
  • Spellman PT; Center for Spatial Systems Biomedicine, Department of Molecular and Medical Genetics, Oregon Health &Science University (OHSU), Portland, Oregon, USA.
  • Li XN; Laboratory of Molecular Neurooncology, Texas Children's Cancer Center, Baylor College of Medicine, Houston, Texas, USA.
  • Keller C; 1] Pediatric Cancer Biology Program, Papé Family Pediatric Research Institute, Department of Pediatrics, OHSU, Portland, Oregon, USA. [2] Children's Cancer Therapy Development Institute, Fort Collins, Colorado, USA.
  • Pal R; Electrical and Computer Engineering, Texas Tech University, Lubbock, Texas, USA.
  • Grill J; 1] CNRS, UMR 8203, Gustave Roussy, Université Paris-Sud, Villejuif, France. [2] Departement de Cancerologie de l'Enfant et de l'Adolescent, Institut Gustave Roussy, Université Paris-Sud, Villejuif, France.
  • Monje M; 1] Department of Neurology, Stanford University, Stanford, California, USA. [2] Department of Neurosurgery, Stanford University, Stanford, California, USA. [3] Department of Pediatrics, Stanford University, Stanford, California, USA. [4] Department of Pathology, Stanford University, Stanford, Califo
Nat Med ; 21(6): 555-9, 2015 Jun.
Article in En | MEDLINE | ID: mdl-25939062
ABSTRACT
Diffuse intrinsic pontine glioma (DIPG) is a fatal childhood cancer. We performed a chemical screen in patient-derived DIPG cultures along with RNA-seq analyses and integrated computational modeling to identify potentially effective therapeutic strategies. The multi-histone deacetylase inhibitor panobinostat demonstrated therapeutic efficacy both in vitro and in DIPG orthotopic xenograft models. Combination testing of panobinostat and the histone demethylase inhibitor GSK-J4 revealed that the two had synergistic effects. Together, these data suggest a promising therapeutic strategy for DIPG.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrimidines / Benzazepines / Brain Stem Neoplasms / Glioma / Hydroxamic Acids / Indoles Limits: Animals / Humans Language: En Journal: Nat Med Journal subject: BIOLOGIA MOLECULAR / MEDICINA Year: 2015 Type: Article Affiliation country: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrimidines / Benzazepines / Brain Stem Neoplasms / Glioma / Hydroxamic Acids / Indoles Limits: Animals / Humans Language: En Journal: Nat Med Journal subject: BIOLOGIA MOLECULAR / MEDICINA Year: 2015 Type: Article Affiliation country: United States