Uvrag targeting by Mir125a and Mir351 modulates autophagy associated with Ewsr1 deficiency.
Autophagy
; 11(5): 796-811, 2015.
Article
in En
| MEDLINE
| ID: mdl-25946189
Key words
AGO2, argonaute; ATG12, autophagy-related 12; ATG14, autophagy-related 14; ATG5, autophagy-related 5; Ant-Mir125a; Ant-Mir351; BECN1, Beclin 1; CNT-Ant, control antagomir; CQ, chloroquine; DGCR8, DiGeorge syndrome critical region gene 8; EWS, Ewing's Sarcoma; EWSR1; EWSR1, EWS RNA-binding protein 1/Ewing Sarcoma Break Point Region 1; Ewsr1+/+; Ewsr1 homozygous knockout; Ewsr1 wild type; ewsr1−/−; LAMP, lysosomal-associated membrane protein; MAP1LC3/LC3; MEF, mouse embryonic fibroblast; Mir125a; Mir125a-specific antagomir; Mir351; Mir351-specific antagomir; Pep.A, pepstatin A; RISC, catalytic component 2; RNA-seq, whole transcriptome sequencing; SQSTM1, sequestosome 1; UVRAG; UVRAG, UV radiation-resistance associated; autophagy; miRNA, microRNA; microtubule-associated protein 1 light chain 3; pri-miRNA, primary transcript miRNA; siRNA, small interfering RNA
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Autophagy
/
Calmodulin-Binding Proteins
/
Tumor Suppressor Proteins
/
MicroRNAs
Type of study:
Risk_factors_studies
Limits:
Animals
Language:
En
Journal:
Autophagy
Year:
2015
Type:
Article