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Discovery of ML358, a Selective Small Molecule Inhibitor of the SKN-1 Pathway Involved in Drug Detoxification and Resistance in Nematodes.
Peddibhotla, Satyamaheshwar; Fontaine, Pauline; Leung, Chi K; Maloney, Patrick; Hershberger, Paul M; Wang, Ying; Bousquet, Michelle S; Luesch, Hendrik; Mangravita-Novo, Arianna; Pinkerton, Anthony B; Smith, Layton H; Malany, Siobhan; Choe, Keith.
Affiliation
  • Peddibhotla S; †Conrad Prebys Center for Chemical Genomics at Sanford-Burnham Medical Research Institute, Orlando, Florida 32827, United States.
  • Fontaine P; ⊥Department of Biology and Genetics Institute, University of Florida, Gainesville, Florida 32611, United States.
  • Leung CK; ⊥Department of Biology and Genetics Institute, University of Florida, Gainesville, Florida 32611, United States.
  • Maloney P; †Conrad Prebys Center for Chemical Genomics at Sanford-Burnham Medical Research Institute, Orlando, Florida 32827, United States.
  • Hershberger PM; †Conrad Prebys Center for Chemical Genomics at Sanford-Burnham Medical Research Institute, Orlando, Florida 32827, United States.
  • Wang Y; ⊥Department of Biology and Genetics Institute, University of Florida, Gainesville, Florida 32611, United States.
  • Bousquet MS; §Department of Medicinal Chemistry, University of Florida, Gainesville, Florida 32610, United States.
  • Luesch H; ∥Center for Natural Products, Drug Discovery and Development, University of Florida, Gainesville, Florida 32610, United States.
  • Mangravita-Novo A; §Department of Medicinal Chemistry, University of Florida, Gainesville, Florida 32610, United States.
  • Pinkerton AB; ∥Center for Natural Products, Drug Discovery and Development, University of Florida, Gainesville, Florida 32610, United States.
  • Smith LH; †Conrad Prebys Center for Chemical Genomics at Sanford-Burnham Medical Research Institute, Orlando, Florida 32827, United States.
  • Malany S; ‡Conrad Prebys Center for Chemical Genomics at Sanford-Burnham Medical Research Institute, La Jolla, California 92037, United States.
  • Choe K; †Conrad Prebys Center for Chemical Genomics at Sanford-Burnham Medical Research Institute, Orlando, Florida 32827, United States.
ACS Chem Biol ; 10(8): 1871-9, 2015 Aug 21.
Article in En | MEDLINE | ID: mdl-25946346
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Transcription Factors / Caenorhabditis elegans / Caenorhabditis elegans Proteins / Small Molecule Libraries / Anthelmintics Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: ACS Chem Biol Year: 2015 Type: Article Affiliation country: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Transcription Factors / Caenorhabditis elegans / Caenorhabditis elegans Proteins / Small Molecule Libraries / Anthelmintics Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: ACS Chem Biol Year: 2015 Type: Article Affiliation country: United States