Iron accumulation in the basal ganglia in Huntington's disease: cross-sectional data from the IMAGE-HD study.
J Neurol Neurosurg Psychiatry
; 87(5): 545-9, 2016 May.
Article
in En
| MEDLINE
| ID: mdl-25952334
ABSTRACT
OBJECTIVES:
To measure iron accumulation in the basal ganglia in Huntington's disease (HD) using quantitative susceptibility mapping (QSM), and to ascertain its relevance in terms of clinical and disease severity.METHODS:
In this cross-sectional investigation, T2* weighted imaging was undertaken on 31 premanifest HD, 32 symptomatic HD and 30 control participants as part of the observational IMAGE-HD study. Group differences in iron accumulation were ascertained with QSM. Associations between susceptibility values and disease severity were also investigated.RESULTS:
Compared with controls, both premanifest and symptomatic HD groups showed significantly greater iron content in pallidum, putamen and caudate. Additionally, iron accumulation in both putamen and caudate was significantly associated with disease severity.CONCLUSIONS:
These findings provide the first evidence that QSM is sensitive to iron deposition in subcortical target areas across premanifest and symptomatic stages of HD. Such findings could open up new avenues for biomarker development and therapeutic intervention.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Basal Ganglia
/
Huntington Disease
/
Iron
Type of study:
Observational_studies
/
Prevalence_studies
/
Risk_factors_studies
Limits:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
J Neurol Neurosurg Psychiatry
Year:
2016
Type:
Article
Affiliation country:
Australia