Structure-Guided Design of Highly Selective and Potent Covalent Inhibitors of ERK1/2.

Ward, Richard A; Colclough, Nicola; Challinor, Mairi; Debreczeni, Judit E; Eckersley, Kay; Fairley, Gary; Feron, Lyman; Flemington, Vikki; Graham, Mark A; Greenwood, Ryan; Hopcroft, Philip; Howard, Tina D; James, Michael; Jones, Clifford D; Jones, Christopher R; Renshaw, Jonathan; Roberts, Karen; Snow, Lindsay; Tonge, Michael; Yeung, Kay

Ward, Richard A; Colclough, Nicola; Challinor, Mairi; Debreczeni, Judit E; Eckersley, Kay; Fairley, Gary; Feron, Lyman; Flemington, Vikki; Graham, Mark A; Greenwood, Ryan; Hopcroft, Philip; Howard, Tina D; James, Michael; Jones, Clifford D; Jones, Christopher R; Renshaw, Jonathan; Roberts, Karen; Snow, Lindsay; Tonge, Michael; Yeung, Kay.

J Med Chem ; 58(11): 4790-801, 2015 Jun 11.

Article in En | MEDLINE | ID: mdl-25977981

Subject(s)

Drug Design; Mitogen-Activated Protein Kinase 1/chemistry; Mitogen-Activated Protein Kinase 3/chemistry; Protein Kinase Inhibitors/pharmacology; Amino Acid Sequence; Cells, Cultured; Crystallography, X-Ray; Humans; Immunoblotting; Models, Molecular; Molecular Sequence Data; Molecular Structure; Protein Kinase Inhibitors/chemistry; Structure-Activity Relationship

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Drug Design / Mitogen-Activated Protein Kinase 1 / Mitogen-Activated Protein Kinase 3 / Protein Kinase Inhibitors Limits: Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2015 Type: Article

Fulltext

XML

PubMed Links

Search on Google