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Intrinsic host restrictions to HIV-1 and mechanisms of viral escape.
Simon, Viviana; Bloch, Nicolin; Landau, Nathaniel R.
Affiliation
  • Simon V; Department of Microbiology, The Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
  • Bloch N; Department of Microbiology, NYU School of Medicine, New York, New York, USA.
  • Landau NR; Department of Microbiology, NYU School of Medicine, New York, New York, USA.
Nat Immunol ; 16(6): 546-53, 2015 Jun.
Article in En | MEDLINE | ID: mdl-25988886
To replicate in their hosts, viruses have to navigate the complexities of the mammalian cell, co-opting mechanisms of cellular physiology while defeating restriction factors that are dedicated to halting their progression. Primate lentiviruses devote a relatively large portion of their coding capacity to counteracting restriction factors by encoding accessory proteins dedicated to neutralizing the antiviral function of these intracellular inhibitors. Research into the roles of the accessory proteins has revealed the existence of previously undetected intrinsic defenses, provided insight into the evolution of primate lentiviruses as they adapt to new species and uncovered new targets for the development of therapeutics. This Review discusses the biology of the restriction factors APOBEC3, SAMHD1 and tetherin and the viral accessory proteins that counteract them.
Subject(s)

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Antigens, CD / HIV Infections / HIV-1 / Monomeric GTP-Binding Proteins / Cytosine Deaminase / Viral Regulatory and Accessory Proteins / Immune Evasion / Host Specificity Limits: Animals / Humans Language: En Journal: Nat Immunol Journal subject: ALERGIA E IMUNOLOGIA Year: 2015 Type: Article Affiliation country: United States

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Antigens, CD / HIV Infections / HIV-1 / Monomeric GTP-Binding Proteins / Cytosine Deaminase / Viral Regulatory and Accessory Proteins / Immune Evasion / Host Specificity Limits: Animals / Humans Language: En Journal: Nat Immunol Journal subject: ALERGIA E IMUNOLOGIA Year: 2015 Type: Article Affiliation country: United States