Osmophobia in allodynic migraineurs: cause or consequence of central sensitization?
Neurol Sci
; 36 Suppl 1: 145-7, 2015 May.
Article
in En
| MEDLINE
| ID: mdl-26017531
ABSTRACT
Migraine is a primary headache characterized by recurrent attacks of head pain associated with nausea or vomit, photophobia, phonophobia and osmophobia. The presence of osmophobia during migraine attacks seems to be a very specific complaint. Cutaneous allodynia (CA) is very common in migraineurs, and it is the most evident clinical manifestation of central sensitization, a mechanism involved in migraine chronification. This study was aimed at identifying the possible correlation between osmophobia and CA in migraineurs. 673 migraineurs were studied (492 episodic, 181 chronic). The prevalence of both CA and osmophobia was higher in chronic than in episodic migraineurs. The association between these two symptoms was significant in chronic migraineurs at Chi square test. The highlighted relationship between CA and osmophobia may be interpreted in different ways central sensitization induced by recurrent pain stimulation may in parallel induce a distortion of both cutaneous sensitivity (CA) and olfaction (osmophobia); alternatively, the recurrent olfactory stimulation in subjects with a hypersensitivity to olfactory stimuli may co-work with repetitive pain stimulation to induce the central sensitization process.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Phobic Disorders
/
Smell
/
Central Nervous System Sensitization
/
Migraine Disorders
Type of study:
Risk_factors_studies
Limits:
Adult
/
Female
/
Humans
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Male
/
Middle aged
Language:
En
Journal:
Neurol Sci
Journal subject:
NEUROLOGIA
Year:
2015
Type:
Article