AMCase is a crucial regulator of type 2 immune responses to inhaled house dust mites.
Proc Natl Acad Sci U S A
; 112(22): E2891-9, 2015 Jun 02.
Article
in En
| MEDLINE
| ID: mdl-26038565
ABSTRACT
Chitinases are enzymes that cleave chitin, a component of the exoskeleton of many organisms including the house dust mite (HDM). Here we show that knockin mice expressing an enzymatically inactive acidic mammalian chitinase (AMCase), the dominant true chitinase in mouse lung, showed enhanced type 2 immune responses to inhaled HDM. We found that uncleaved chitin promoted the release of IL-33, whereas cleaved chitin could be phagocytosed and could induce the activation of caspase-1 and subsequent activation of caspase-7; this results in the resolution of type 2 immune responses, probably by promoting the inactivation of IL-33. These data suggest that AMCase is a crucial regulator of type 2 immune responses to inhaled chitin-containing aeroallergens.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Asthma
/
Chitinases
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Pyroglyphidae
/
Disease Models, Animal
Limits:
Animals
Language:
En
Journal:
Proc Natl Acad Sci U S A
Year:
2015
Type:
Article