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Liposome encapsulated curcumin-difluorinated (CDF) inhibits the growth of cisplatin resistant head and neck cancer stem cells.
Basak, Saroj K; Zinabadi, Alborz; Wu, Arthur W; Venkatesan, Natarajan; Duarte, Victor M; Kang, James J; Dalgard, Clifton L; Srivastava, Meera; Sarkar, Fazlul H; Wang, Marilene B; Srivatsan, Eri S.
Affiliation
  • Basak SK; Department of Surgery, VA Greater Los Angeles Healthcare System, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA, USA.
  • Zinabadi A; Department of Surgery, VA Greater Los Angeles Healthcare System, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA, USA.
  • Wu AW; Department of Surgery, VA Greater Los Angeles Healthcare System, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA, USA.
  • Venkatesan N; Department of Surgery, VA Greater Los Angeles Healthcare System, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA, USA.
  • Duarte VM; Department of Surgery, VA Greater Los Angeles Healthcare System, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA, USA.
  • Kang JJ; Department of Head and Neck Surgery, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA, USA.
  • Dalgard CL; Department of Surgery, VA Greater Los Angeles Healthcare System, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA, USA.
  • Srivastava M; Departments of Anatomy, Physiology and Genetics, Molecular and Cell Biology, Uniformed Services University, Bethesda, MD, USA.
  • Sarkar FH; Departments of Anatomy, Physiology and Genetics, Molecular and Cell Biology, Uniformed Services University, Bethesda, MD, USA.
  • Wang MB; Karmanos Cancer Institute, Wayne State University, Detroit, MI, USA.
  • Srivatsan ES; Department of Surgery, VA Greater Los Angeles Healthcare System, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA, USA.
Oncotarget ; 6(21): 18504-17, 2015 Jul 30.
Article in En | MEDLINE | ID: mdl-26098778
Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer, with 600,000 new cases every year worldwide. Although chemotherapeutics exist, five-year survival is only 50%. New strategies to overcome drug resistance are required to improve HNSCC treatment. Curcumin-difluorinated (CDF), a synthetic analog of curcumin, was packaged in liposomes and used to evaluate growth inhibition of cisplatin resistant HNSCC cell lines CCL-23R and UM-SCC-1R generated from the parental cell lines CCL-23 and UM-SCC-1 respectively. Growth inhibition in vitro and expression levels of the CD44 (cancer stem cell marker), cytokines, and growth factors were investigated after liposomal CDF treatment. The in vivo growth inhibitory effect of liposomal CDF was evaluated in the nude mice xenograft tumor model of UM-SCC-1R and the inhibition of CD44 was measured. Treatment of the resistant cell lines in vitro with liposomal CDF resulted in a statistically significant growth inhibition (p < 0.05). The nude mice xenograft study showed a statistically significant tumor growth inhibition of UM-SCC-1R cells and a reduction in the expression of CD44 (p < 0.05), indicating an inhibitory effect of liposomal CDF on CSCs. Our results demonstrate that delivery of CDF through liposomes may be an effective method for the treatment of cisplatin resistant HNSCC.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Neoplastic Stem Cells / Carcinoma, Squamous Cell / Curcumin / Cell Proliferation / Head and Neck Neoplasms / Hydrocarbons, Fluorinated Type of study: Prognostic_studies Limits: Animals / Female / Humans Language: En Journal: Oncotarget Year: 2015 Type: Article Affiliation country: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Neoplastic Stem Cells / Carcinoma, Squamous Cell / Curcumin / Cell Proliferation / Head and Neck Neoplasms / Hydrocarbons, Fluorinated Type of study: Prognostic_studies Limits: Animals / Female / Humans Language: En Journal: Oncotarget Year: 2015 Type: Article Affiliation country: United States