[Clinical significance of determination of serum IgE in infants with milk allergy].
Zhongguo Dang Dai Er Ke Za Zhi
; 17(6): 618-22, 2015 Jun.
Article
in Zh
| MEDLINE
| ID: mdl-26108326
ABSTRACT
OBJECTIVE:
To determine the clinical significance of milk protein-specific IgE (sIgE) for infants with cow's milk protein allergy (CMPA).METHODS:
Ninety-six infants with CMPA were divided into IgE+ group (n=26) and IgE- group (n=70) and clinical characteristics were compared between the two groups. Infants were denied allergy-inducing food and fed instead extensively hydrolyzed formulas or amino-acid formulas for 16 weeks before the two groups were compared.RESULTS:
Twenty-seven percent of the infants were sIgE-seropositive. The first onset age of CMPA was significantly younger in the IgE+ group than in the IgE- group (P<0.05), and the family history of allergy and respiratory symptoms were significantly less common in the IgE- group than in the IgE+ group (P<0.05). Severe CMPA, gastrointestinal symptoms, underweight, growth retardation, anemia, and hypoproteinemia were significantly more common in the IgE- group than in the IgE+ group (P<0.05). Erythema, urticaria, vomiting, nasal discharge, cough, wheezing, and paroxysms of crying were major clinical symptoms of the IgE+ group, and their incidences were significantly higher in the IgE+ group than in the IgE- group (P<0.05); eczema, constipation, and diarrhea were major symptoms of the IgE- group, and their incidences were significantly higher in the IgE- group than in the IgE+ group (P<0.05). The remission rate of each symptom was as high as over 80% in the two groups after 16 weeks of intervention and there was no significant difference in the remission rates between the two groups (P>0.05).CONCLUSIONS:
IgE seropositive rate is not high in infants with CMPA. Atypical signs instead of allergic symptoms are more common in the IgE seronegative infants with CMPA. Avoiding allergy-inducing food and eating extensively hydrolyzed formulas or amino-acid formulas in early age benefit infants with IgE-mediated or non-IgE-mediated CMPA.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Immunoglobulin E
/
Milk Hypersensitivity
Type of study:
Observational_studies
/
Prognostic_studies
Limits:
Female
/
Humans
/
Infant
/
Male
Language:
Zh
Journal:
Zhongguo Dang Dai Er Ke Za Zhi
Year:
2015
Type:
Article
Affiliation country:
China