[Dual role for prostaglandin D2 in intestinal epithelial homeostasis]. / Prostaglandine D2 et homéostasie de la barrière épithéliale intestinale--Une relation équivoque.
Med Sci (Paris)
; 31(6-7): 617-21, 2015.
Article
in Fr
| MEDLINE
| ID: mdl-26152165
ABSTRACT
Prostaglandin D2 (PGD2) and derivatives are lipid mediators involved in the control of the intestinal epithelial barrier homeostasis. Their involvement in the pathophysiology of chronic inflammatory bowel disease (IBD) is still debated. Several results highlight the duality of PGD2 as an anti- or pro-inflammatory mediator. This duality seems to be related to a differential expression of its receptors by intestinal epithelial cells and the surrounding immunocompetent cells. The enteric glial cells from the enteric nervous system (ENS) express the lipocalin-type-prostaglandin D synthase and secrete PGD2 and 15d-PGJ2. The protective role of the ENS in the homeostatic control of the epithelial intestinal barrier and its involvement in the pathogenesis of IBD have already been demonstrated. Thus, these lipid mediators seem to be new actors of the neuro-glio-epithelial unit and could play a crucial role maintaining gut barrier integrity.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Prostaglandin D2
/
Epithelial Cells
/
Homeostasis
/
Intestinal Mucosa
Type of study:
Etiology_studies
Limits:
Animals
/
Humans
Language:
Fr
Journal:
Med Sci (Paris)
Journal subject:
MEDICINA
Year:
2015
Type:
Article
Affiliation country:
France