Synthesis and biological evaluation of a novel betulinic acid derivative as an inducer of apoptosis in human colon carcinoma cells (HT-29).

Chakraborty, Biswajit; Dutta, Debasmita; Mukherjee, Sanjukta; Das, Supriya; Maiti, Nakul C; Das, Padma; Chowdhury, Chinmay

Chakraborty, Biswajit; Dutta, Debasmita; Mukherjee, Sanjukta; Das, Supriya; Maiti, Nakul C; Das, Padma; Chowdhury, Chinmay.

Affiliation

Chakraborty B; Organic and Medicinal Chemistry Division, CSIR-Indian Institute of Chemical Biology, 4 Raja S. C. Mullick Road, Kolkata 700032, India.
Dutta D; Cancer Biology and Inflammatory Disorder Division, CSIR-Indian Institute of Chemical Biology, 4 Raja S. C. Mullick Road, Kolkata 700032, India.
Mukherjee S; Organic and Medicinal Chemistry Division, CSIR-Indian Institute of Chemical Biology, 4 Raja S. C. Mullick Road, Kolkata 700032, India.
Das S; Structural Biology and Bioinformatics Division, CSIR-Indian Institute of Chemical Biology, 4 Raja S. C. Mullick Road, Kolkata 700032, India.
Maiti NC; Structural Biology and Bioinformatics Division, CSIR-Indian Institute of Chemical Biology, 4 Raja S. C. Mullick Road, Kolkata 700032, India.
Das P; Cancer Biology and Inflammatory Disorder Division, CSIR-Indian Institute of Chemical Biology, 4 Raja S. C. Mullick Road, Kolkata 700032, India. Electronic address: padmadas@iicb.res.in.
Chowdhury C; Organic and Medicinal Chemistry Division, CSIR-Indian Institute of Chemical Biology, 4 Raja S. C. Mullick Road, Kolkata 700032, India. Electronic address: chinmay@iicb.res.in.

Eur J Med Chem ; 102: 93-105, 2015 Sep 18.

Article in En | MEDLINE | ID: mdl-26248310

Subject(s)

Antineoplastic Agents/chemical synthesis; Antineoplastic Agents/pharmacology; Apoptosis/drug effects; Triterpenes/chemistry; Triterpenes/pharmacology; Antineoplastic Agents/chemistry; Cell Line; Cell Proliferation/drug effects; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; HT29 Cells; Humans; Molecular Structure; Pentacyclic Triterpenes; Reactive Oxygen Species/metabolism; Structure-Activity Relationship; Betulinic Acid

Key words

Betulinic acid; Caspase activation; Cytotoxic activities; DNA binding; Mitochondrial dysfunction; Triazole derivative

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Triterpenes / Apoptosis / Antineoplastic Agents Limits: Humans Language: En Journal: Eur J Med Chem Year: 2015 Type: Article Affiliation country: India

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