ROCK insufficiency attenuates ozone-induced airway hyperresponsiveness in mice.

Kasahara, David I; Mathews, Joel A; Park, Chan Y; Cho, Youngji; Hunt, Gabrielle; Wurmbrand, Allison P; Liao, James K; Shore, Stephanie A

Kasahara, David I; Mathews, Joel A; Park, Chan Y; Cho, Youngji; Hunt, Gabrielle; Wurmbrand, Allison P; Liao, James K; Shore, Stephanie A.

Affiliation

Kasahara DI; Molecular and Integrative Physiological Sciences Program, Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts; and dkasahar@hsph.harvard.edu.
Mathews JA; Molecular and Integrative Physiological Sciences Program, Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts; and.
Park CY; Molecular and Integrative Physiological Sciences Program, Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts; and.
Cho Y; Molecular and Integrative Physiological Sciences Program, Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts; and.
Hunt G; Molecular and Integrative Physiological Sciences Program, Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts; and.
Wurmbrand AP; Molecular and Integrative Physiological Sciences Program, Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts; and.
Liao JK; Department of Medicine, University of Chicago, Chicago, Illinois.
Shore SA; Molecular and Integrative Physiological Sciences Program, Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts; and.

Am J Physiol Lung Cell Mol Physiol ; 309(7): L736-46, 2015 Oct 01.

Article in En | MEDLINE | ID: mdl-26276827

Subject(s)

Bronchial Hyperreactivity; Oxidants, Photochemical/adverse effects; Ozone/adverse effects; Pneumonia; rho-Associated Kinases/biosynthesis; Animals; Bronchial Hyperreactivity/chemically induced; Bronchial Hyperreactivity/genetics; Bronchial Hyperreactivity/metabolism; Bronchial Hyperreactivity/pathology; Bronchial Hyperreactivity/physiopathology; Dose-Response Relationship, Drug; Gene Expression Regulation, Enzymologic/drug effects; Humans; Interleukin-17/genetics; Interleukin-17/metabolism; Mice; Mice, Mutant Strains; Muscle Contraction/drug effects; Muscle Contraction/genetics; Muscle, Smooth/metabolism; Muscle, Smooth/pathology; Muscle, Smooth/physiopathology; Osteopontin/genetics; Osteopontin/metabolism; Oxidants, Photochemical/pharmacology; Ozone/pharmacology; Pneumonia/chemically induced; Pneumonia/genetics; Pneumonia/metabolism; Pneumonia/pathology; Pneumonia/physiopathology; Tumor Necrosis Factor-alpha/genetics; Tumor Necrosis Factor-alpha/metabolism; rho-Associated Kinases/genetics

Key words

bronchoalveolar lavage; fasudil; hyaluronan; inflammation; osteopontin

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oxidants, Photochemical / Ozone / Pneumonia / Bronchial Hyperreactivity / Rho-Associated Kinases Limits: Animals / Humans Language: En Journal: Am J Physiol Lung Cell Mol Physiol Journal subject: BIOLOGIA MOLECULAR / FISIOLOGIA Year: 2015 Type: Article

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