An interactive genome browser of association results from the UK10K cohorts project.
Bioinformatics
; 31(24): 4029-31, 2015 Dec 15.
Article
in En
| MEDLINE
| ID: mdl-26315906
ABSTRACT
UNLABELLED High-throughput sequencing technologies survey genetic variation at genome scale and are increasingly used to study the contribution of rare and low-frequency genetic variants to human traits. As part of the Cohorts arm of the UK10K project, genetic variants called from low-read depth (average 7×) whole genome sequencing of 3621 cohort individuals were analysed for statistical associations with 64 different phenotypic traits of biomedical importance. Here, we describe a novel genome browser based on the Biodalliance platform developed to provide interactive access to the association results of the project. AVAILABILITY AND IMPLEMENTATION The browser is available at http//www.uk10k.org/dalliance.html. Source code for the Biodalliance platform is available under a BSD license from http//github.com/dasmoth/dalliance, and for the LD-display plugin and backend from http//github.com/dasmoth/ldserv.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Genetic Variation
/
Software
/
Genome, Human
/
Genetic Association Studies
Type of study:
Risk_factors_studies
Limits:
Humans
Language:
En
Journal:
Bioinformatics
Journal subject:
INFORMATICA MEDICA
Year:
2015
Type:
Article
Affiliation country:
United kingdom