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Actin shapes the autophagosome.
Holland, Petter; Simonsen, Anne.
Affiliation
  • Holland P; Department of Molecular Medicine, Insititute of Basic Medical Sciences, University of Oslo, 0317 Oslo, Norway.
  • Simonsen A; Department of Molecular Medicine, Insititute of Basic Medical Sciences, University of Oslo, 0317 Oslo, Norway.
Nat Cell Biol ; 17(9): 1094-6, 2015 Sep.
Article in En | MEDLINE | ID: mdl-26316454
Compared with most intracellular vesicles, the autophagosome is formed by an unusual event of vesicle budding involving an elusive sequence of membrane expansions that ends with a double membrane vesicle. It is now shown that actin polymerization inside the forming autophagosome is a driving force for the expansion and assembly of a functional autophagosome.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Autophagy / Actin Cytoskeleton / Phagosomes / CapZ Actin Capping Protein / Intracellular Membranes Limits: Animals Language: En Journal: Nat Cell Biol Year: 2015 Type: Article Affiliation country: Norway
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Autophagy / Actin Cytoskeleton / Phagosomes / CapZ Actin Capping Protein / Intracellular Membranes Limits: Animals Language: En Journal: Nat Cell Biol Year: 2015 Type: Article Affiliation country: Norway