Interferon-&#945; induces marked alterations in circulating regulatory T cells, NK cell subsets, and dendritic cells in patients with JAK2V617F-positive essential thrombocythemia and polycythemia vera.

Riley, Caroline H; Brimnes, Marie K; Hansen, Morten; Jensen, Morten Krogh; Hasselbalch, Hans C; Kjaer, Lasse; Straten, Per Thor; Svane, Inge Marie

Interferon-α induces marked alterations in circulating regulatory T cells, NK cell subsets, and dendritic cells in patients with JAK2V617F-positive essential thrombocythemia and polycythemia vera.

Riley, Caroline H; Brimnes, Marie K; Hansen, Morten; Jensen, Morten Krogh; Hasselbalch, Hans C; Kjaer, Lasse; Straten, Per Thor; Svane, Inge Marie.

Affiliation

Riley CH; Department of Haematology, Herlev Hospital, University of Copenhagen, Copenhagen, Denmark.
Brimnes MK; Center for Cancer Immune Therapy, Herlev Hospital, University of Copenhagen, Copenhagen, Denmark.
Hansen M; Institute for Inflammation Research, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Jensen MK; Center for Cancer Immune Therapy, Herlev Hospital, University of Copenhagen, Copenhagen, Denmark.
Hasselbalch HC; Department of Haematology, Roskilde Hospital, University of Copenhagen, Denmark.
Kjaer L; Department of Haematology, Roskilde Hospital, University of Copenhagen, Denmark.
Straten PT; Department of Haematology, Roskilde Hospital, University of Copenhagen, Denmark.
Svane IM; Center for Cancer Immune Therapy, Herlev Hospital, University of Copenhagen, Copenhagen, Denmark.

Eur J Haematol ; 97(1): 83-92, 2016 Jul.

Article in En | MEDLINE | ID: mdl-26385526

Subject(s)

Dendritic Cells; Interferon-alpha/therapeutic use; Killer Cells, Natural; Polycythemia Vera/blood; Polycythemia Vera/drug therapy; T-Lymphocytes, Regulatory; Thrombocythemia, Essential/blood; Thrombocythemia, Essential/drug therapy; Adult; Aged; Biomarkers; Chemokines/blood; Codon; Dendritic Cells/drug effects; Dendritic Cells/metabolism; Female; Humans; Immunophenotyping; Interferon-alpha/pharmacology; Janus Kinase 2/genetics; Killer Cells, Natural/drug effects; Killer Cells, Natural/metabolism; Male; Middle Aged; Mutation; Phenotype; Polycythemia Vera/diagnosis; Polycythemia Vera/genetics; T-Lymphocyte Subsets/metabolism; T-Lymphocytes, Regulatory/drug effects; T-Lymphocytes, Regulatory/metabolism; Thrombocythemia, Essential/diagnosis; Thrombocythemia, Essential/genetics; Treatment Outcome

Key words

IFN-α treatment; JAK2-positive MPNs; immune cells

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Polycythemia Vera / Dendritic Cells / Killer Cells, Natural / Interferon-alpha / T-Lymphocytes, Regulatory / Thrombocythemia, Essential Type of study: Diagnostic_studies Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: En Journal: Eur J Haematol Journal subject: HEMATOLOGIA Year: 2016 Type: Article Affiliation country: Denmark

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