Mitochondrial metabolic failure in telomere attrition-provoked aging of bone marrow mesenchymal stem cells.
Biogerontology
; 17(2): 267-79, 2016 Apr.
Article
in En
| MEDLINE
| ID: mdl-26392399
ABSTRACT
The proliferation and differentiation potential of bone marrow mesenchymal stem cells (BMMSCs) declines with age and with in vitro passages. However, the underlying mechanisms and putative approaches to maintain their function are not fully understood. Recent studies have revealed telomere attrition as the core initiator determining functional decline in aging of BMMSCs. Telomere attrition activates downstream p53 signaling and compromises mitochondrial metabolism via the peroxisome proliferator-activated receptor gamma co-activator 1α/ß (PGC-1α/ß), a key process possesses peculiarities in BMMSCs distinct from other stem cells and their mature derivatives. Despite of the shortened telomere, the mitochondrial failure could be overcome through metabolic regulation by caloric restriction (CR) and its mediator Sirtuin 1 (SIRT1). Researches have shown that mitochondrial metabolic reprogramming by CR and SIRT1 alleviates functional decline of BMMSCs in aging. In this review, we intend to summarize our understanding about how telomere attrition initiates and induces mitochondrial compromise in functional decline of BMMSCs in aging, and the potential therapeutic strategies based on metabolic reprogramming.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Bone Marrow Cells
/
Telomere
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Cellular Senescence
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Mesenchymal Stem Cells
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Mitochondria
Limits:
Animals
/
Humans
Language:
En
Journal:
Biogerontology
Journal subject:
GERIATRIA
Year:
2016
Type:
Article