Antineoplastic Combined Chemotherapy Protocols/administration & dosage; Antineoplastic Combined Chemotherapy Protocols/pharmacokinetics; Quinazolines/administration & dosage; Quinazolines/pharmacokinetics; Urinary Bladder Neoplasms/drug therapy; Aged; Antineoplastic Combined Chemotherapy Protocols/adverse effects; Biomarkers, Tumor/analysis; Bone Neoplasms/drug therapy; Bone Neoplasms/secondary; Cisplatin/administration & dosage; Deoxycytidine/administration & dosage; Deoxycytidine/analogs & derivatives; Dose-Response Relationship, Drug; Drug Administration Schedule; ErbB Receptors/analysis; Febrile Neutropenia/chemically induced; Female; Humans; International Cooperation; Lapatinib; Liver Neoplasms/drug therapy; Liver Neoplasms/secondary; Lung Neoplasms/drug therapy; Lung Neoplasms/secondary; Lymphatic Metastasis; Male; Maximum Tolerated Dose; Middle Aged; Quinazolines/adverse effects; Receptor, ErbB-2/analysis; Renal Insufficiency/chemically induced; Treatment Outcome; Urinary Bladder Neoplasms/pathology; Gemcitabine