High Expression of Cathepsin E is Associated with the Severity of Airflow Limitation in Patients with COPD.
COPD
; 13(2): 160-6, 2016.
Article
in En
| MEDLINE
| ID: mdl-26488201
ABSTRACT
BACKGROUND:
It was reported that Cathepsin E (Cat E) plays a critical role in antigen processing and in the development of pulmonary emphysema. The aim of this study was to investigate the role of Cat E and airflow limitation in the pathogenesis of COPD.METHODS:
Sixty-five patients with COPD, 20 smoking control subjects without COPD and 15 non-smoking healthy control subjects were enrolled. Cat E and EIC (Elastase inhibitory capacity) expressions were measured by ELISA in sputum and serum samples and compared according to different subgroups.RESULTS:
Cat E concentrations were significantly higher in patients with COPD than smoking control and non-smoking control subjects (P < 0.01). The levels of CatE were inversely correlated with FEV1% predicted in COPD patients (r = -0.95, P < 0.01). The levels of EIC were inversely positively correlated with FEV1% predicted in COPD patients (r = 0.926, P < 0.01). Levels of Cat E were also inversely correlated with the levels of EIC (r = -0.922, P < 0.01).CONCLUSIONS:
Cat E contributes to the severity of airflow limitation during progression of COPD.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pulmonary Emphysema
/
Sputum
/
Cathepsin E
/
Pulmonary Disease, Chronic Obstructive
Type of study:
Prognostic_studies
/
Risk_factors_studies
Limits:
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
COPD
Year:
2016
Type:
Article
Affiliation country:
China