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Dasatinib blocks transcriptional and promigratory responses to transforming growth factor-beta in pancreatic adenocarcinoma cells through inhibition of Smad signalling: implications for in vivo mode of action.
Bartscht, Tobias; Rosien, Benjamin; Rades, Dirk; Kaufmann, Roland; Biersack, Harald; Lehnert, Hendrik; Gieseler, Frank; Ungefroren, Hendrik.
Affiliation
  • Bartscht T; First Department of Medicine, UKSH, Campus Lübeck, 23538, Lübeck, Germany.
  • Rosien B; First Department of Medicine, UKSH, Campus Lübeck, 23538, Lübeck, Germany.
  • Rades D; Department of Radiation Oncology, UKSH, Campus Lübeck, D-23538, Lübeck, Germany.
  • Kaufmann R; Department of General, Visceral and Vascular Surgery, Jena University Hospital, D-07747, Jena, Germany.
  • Biersack H; First Department of Medicine, UKSH, Campus Lübeck, 23538, Lübeck, Germany.
  • Lehnert H; First Department of Medicine, UKSH, Campus Lübeck, 23538, Lübeck, Germany.
  • Gieseler F; First Department of Medicine, UKSH, Campus Lübeck, 23538, Lübeck, Germany.
  • Ungefroren H; First Department of Medicine, UKSH, Campus Lübeck, 23538, Lübeck, Germany. hendrik.ungefroren@uksh.de.
Mol Cancer ; 14: 199, 2015 Nov 21.
Article in En | MEDLINE | ID: mdl-26588899
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pancreatic Neoplasms / Transcription, Genetic / Carcinoma, Pancreatic Ductal / Transforming Growth Factor beta1 / Dasatinib / Antineoplastic Agents Limits: Humans Language: En Journal: Mol Cancer Journal subject: NEOPLASIAS Year: 2015 Type: Article Affiliation country: Germany
Fulltext
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pancreatic Neoplasms / Transcription, Genetic / Carcinoma, Pancreatic Ductal / Transforming Growth Factor beta1 / Dasatinib / Antineoplastic Agents Limits: Humans Language: En Journal: Mol Cancer Journal subject: NEOPLASIAS Year: 2015 Type: Article Affiliation country: Germany