Short peptides from leucyl-tRNA synthetase rescue disease-causing mitochondrial tRNA point mutations.

Perli, Elena; Fiorillo, Annarita; Giordano, Carla; Pisano, Annalinda; Montanari, Arianna; Grazioli, Paola; Campese, Antonio F; Di Micco, Patrizio; Tuppen, Helen A; Genovese, Ilaria; Poser, Elena; Preziuso, Carmela; Taylor, Robert W; Morea, Veronica; Colotti, Gianni; d'Amati, Giulia

Perli, Elena; Fiorillo, Annarita; Giordano, Carla; Pisano, Annalinda; Montanari, Arianna; Grazioli, Paola; Campese, Antonio F; Di Micco, Patrizio; Tuppen, Helen A; Genovese, Ilaria; Poser, Elena; Preziuso, Carmela; Taylor, Robert W; Morea, Veronica; Colotti, Gianni; d'Amati, Giulia.

Affiliation

Perli E; Department of Radiology, Oncology and Pathology.
Fiorillo A; Department of Biochemical Sciences "A. Rossi Fanelli".
Giordano C; Department of Radiology, Oncology and Pathology.
Pisano A; Department of Radiology, Oncology and Pathology.
Montanari A; Department of Biology and Biotechnologies 'Charles Darwin' and Pasteur Institute-Cenci Bolognetti Foundation, Rome 00161, Italy.
Grazioli P; Department of Molecular Medicine, Sapienza University of Rome, Rome 00161, Italy.
Campese AF; Department of Molecular Medicine, Sapienza University of Rome, Rome 00161, Italy.
Di Micco P; Department of Biochemical Sciences "A. Rossi Fanelli".
Tuppen HA; Wellcome Trust Center for Mitochondrial Research, Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne NE1 7RU, UK and.
Genovese I; Department of Biochemical Sciences "A. Rossi Fanelli".
Poser E; Department of Biochemical Sciences "A. Rossi Fanelli".
Preziuso C; Department of Radiology, Oncology and Pathology.
Taylor RW; Wellcome Trust Center for Mitochondrial Research, Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne NE1 7RU, UK and.
Morea V; National Research Council of Italy, Institute of Molecular Biology and Pathology, Rome 00185, Italy.
Colotti G; National Research Council of Italy, Institute of Molecular Biology and Pathology, Rome 00185, Italy giulia.damati@uniroma1.it gianni.colotti@uniroma1.it.
d'Amati G; Department of Radiology, Oncology and Pathology, Pasteur Institute-Cenci Bolognetti Foundation, Rome 00161, Italy, giulia.damati@uniroma1.it gianni.colotti@uniroma1.it.

Hum Mol Genet ; 25(5): 903-15, 2016 Mar 01.

Article in En | MEDLINE | ID: mdl-26721932

Subject(s)

Amino Acyl-tRNA Synthetases/genetics; Mitochondria/drug effects; Osteoblasts/drug effects; Peptides/pharmacology; Point Mutation; Amino Acid Sequence; Amino Acyl-tRNA Synthetases/metabolism; Apoptosis/drug effects; Cell Line, Tumor; Cell Proliferation/drug effects; Gene Expression; Humans; MELAS Syndrome/genetics; MELAS Syndrome/metabolism; MELAS Syndrome/pathology; MERRF Syndrome/genetics; MERRF Syndrome/metabolism; MERRF Syndrome/pathology; Mitochondria/metabolism; Mitochondria/pathology; Models, Molecular; Molecular Sequence Data; Osteoblasts/metabolism; Osteoblasts/pathology; Peptides/chemical synthesis; Phenotype; Protein Domains; Protein Structure, Secondary; RNA, Transfer, Leu/metabolism; RNA, Transfer, Lys/metabolism; Sequence Alignment

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Osteoblasts / Peptides / Point Mutation / Amino Acyl-tRNA Synthetases / Mitochondria Limits: Humans Language: En Journal: Hum Mol Genet Journal subject: BIOLOGIA MOLECULAR / GENETICA MEDICA Year: 2016 Type: Article

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