Lipid Nanoparticles Composed of Quaternary Amine-Tertiary Amine Cationic Lipid Combination (QTsome) for Therapeutic Delivery of AntimiR-21 for Lung Cancer.

Yung, Bryant C; Li, Jilong; Zhang, Mengzi; Cheng, Xinwei; Li, Hong; Yung, Elaine M; Kang, Chen; Cosby, Lauren E; Liu, Yang; Teng, Lesheng; Lee, Robert J

Yung, Bryant C; Li, Jilong; Zhang, Mengzi; Cheng, Xinwei; Li, Hong; Yung, Elaine M; Kang, Chen; Cosby, Lauren E; Liu, Yang; Teng, Lesheng; Lee, Robert J.

Affiliation

Teng L; College of Life Sciences, Jilin University , Changchun, China.
Lee RJ; College of Life Sciences, Jilin University , Changchun, China.

Mol Pharm ; 13(2): 653-62, 2016 Feb 01.

Article in En | MEDLINE | ID: mdl-26741162

Subject(s)

Amines/chemistry; Cations/chemistry; Drug Delivery Systems; Lipids/chemistry; Lung Neoplasms/therapy; MicroRNAs/antagonists & inhibitors; Nanoparticles/administration & dosage; Animals; Antineoplastic Agents, Phytogenic/pharmacology; Apoptosis/drug effects; Blotting, Western; Cell Movement/drug effects; Cell Proliferation/drug effects; Combined Modality Therapy; Female; Humans; Immunoenzyme Techniques; Liposomes; Lung Neoplasms/genetics; Lung Neoplasms/pathology; Mice; Mice, Nude; MicroRNAs/genetics; Nanoparticles/chemistry; Paclitaxel/pharmacology; RNA, Messenger/genetics; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; Tumor Cells, Cultured; Xenograft Model Antitumor Assays

Key words

RNA interference; cancer; drug delivery; gene regulation; microRNA; nanoparticles; noncoding RNA

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cations / Drug Delivery Systems / MicroRNAs / Nanoparticles / Amines / Lipids / Lung Neoplasms Limits: Animals / Female / Humans Language: En Journal: Mol Pharm Journal subject: BIOLOGIA MOLECULAR / FARMACIA / FARMACOLOGIA Year: 2016 Type: Article

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