Cdc42 and k-Ras Control Endothelial Tubulogenesis through Apical Membrane and Cytoskeletal Polarization: Novel Stimulatory Roles for GTPase Effectors, the Small GTPases, Rac2 and Rap1b, and Inhibitory Influence of Arhgap31 and Rasa1.

Norden, Pieter R; Kim, Dae Joong; Barry, David M; Cleaver, Ondine B; Davis, George E

Norden, Pieter R; Kim, Dae Joong; Barry, David M; Cleaver, Ondine B; Davis, George E.

Affiliation

Norden PR; Department of Medical Pharmacology and Physiology, University of Missouri School of Medicine, Dalton Cardiovascular Research Center, Columbia, MO, United States of America.
Kim DJ; Department of Medical Pharmacology and Physiology, University of Missouri School of Medicine, Dalton Cardiovascular Research Center, Columbia, MO, United States of America.
Barry DM; Department of Molecular Biology, UT Southwestern Medical Center, Dallas, TX, United States of America.
Cleaver OB; Department of Molecular Biology, UT Southwestern Medical Center, Dallas, TX, United States of America.
Davis GE; Department of Medical Pharmacology and Physiology, University of Missouri School of Medicine, Dalton Cardiovascular Research Center, Columbia, MO, United States of America.

PLoS One ; 11(1): e0147758, 2016.

Article in En | MEDLINE | ID: mdl-26812085

Subject(s)

Cytoskeleton/metabolism; GTPase-Activating Proteins/metabolism; Phosphoproteins/metabolism; cdc42 GTP-Binding Protein/metabolism; p120 GTPase Activating Protein/metabolism; rac GTP-Binding Proteins/metabolism; rap GTP-Binding Proteins/metabolism; ras Proteins/metabolism; Animals; Cell Line; Endothelial Cells/cytology; Endothelial Cells/drug effects; Endothelial Cells/metabolism; Female; GTPase-Activating Proteins/antagonists & inhibitors; GTPase-Activating Proteins/genetics; Humans; Male; Mice; Microscopy, Fluorescence; Phorbol Esters/pharmacology; Phosphoproteins/antagonists & inhibitors; Phosphoproteins/genetics; RNA Interference; Signal Transduction/drug effects; Tubulin/metabolism; Vacuoles/metabolism; cdc42 GTP-Binding Protein/antagonists & inhibitors; cdc42 GTP-Binding Protein/genetics; p120 GTPase Activating Protein/antagonists & inhibitors; p120 GTPase Activating Protein/genetics; rac GTP-Binding Proteins/antagonists & inhibitors; rac GTP-Binding Proteins/genetics; rap GTP-Binding Proteins/antagonists & inhibitors; rap GTP-Binding Proteins/genetics; ras Proteins/antagonists & inhibitors; ras Proteins/genetics; RAC2 GTP-Binding Protein

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phosphoproteins / Cytoskeleton / Ras Proteins / Rap GTP-Binding Proteins / Cdc42 GTP-Binding Protein / Rac GTP-Binding Proteins / GTPase-Activating Proteins / P120 GTPase Activating Protein Limits: Animals / Female / Humans / Male Language: En Journal: PLoS One Journal subject: CIENCIA / MEDICINA Year: 2016 Type: Article Affiliation country: United States

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