Antihypertensive agents and the risk of breast cancer in women aged 55 years and older: a nested case-control study.
J Hypertens
; 34(3): 558-66; discussion 566, 2016 Mar.
Article
in En
| MEDLINE
| ID: mdl-26818924
ABSTRACT
OBJECTIVE:
The study aimed to investigate the association of long-term use of different antihypertensive agents with incident breast cancer.METHODS:
A total of 794â,533 women aged at least 55 years were identified from Taiwan National Health Insurance claims database during 2001-2011. As of 31 December 2011, incident breast cancer patients were included as cases, and 1ââ4 age-matched controls were selected by risk-set sampling scheme. Logistic regression models were applied to estimate the odds ratios (ORs) and 95% confidence intervals (CIs) of breast cancer incidence associated with different durations of use of angiotensin-converting enzyme inhibitors/angiotensin receptor blockers, ß-blockers, and dihydropyridine calcium channel blockers (DHP CCBs). Different restriction rules were applied to reveal the potential effects of confounding by indication.RESULTS:
Among the 9397 incident breast cancer patients and 37â,588 controls, a significantly elevated risk was found for relatively short-term use of DHP CCBs (<6 years) but not in those observed for more than 6 years. There was no association between either angiotensin-converting enzyme inhibitors/angiotensin receptor blockers or ß-blockers use and breast cancer. Although restricting our analyses to those with any prescription of antihypertensive medications in 2001 or those with diagnosis of hypertension, there was no longer a statistically significant association between any use of DHP CCBs and breast cancer (OR 1.21, 95% CI 0.88-1.67 for the former, and OR 1.71, 95% CI 0.99-2.95 for the latter).CONCLUSION:
The results demonstrated the potential effect of confounding by indication, and thus, did not suggest any association of the use of antihypertensive medication and breast cancer risk.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Breast Neoplasms
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Angiotensin-Converting Enzyme Inhibitors
/
Calcium Channel Blockers
/
Adrenergic beta-Antagonists
/
Angiotensin Receptor Antagonists
/
Hypertension
/
Antihypertensive Agents
Type of study:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Aged
/
Female
/
Humans
/
Middle aged
Country/Region as subject:
Asia
Language:
En
Journal:
J Hypertens
Year:
2016
Type:
Article
Affiliation country:
Taiwan