Maternal Tenofovir Disoproxil Fumarate Use in Pregnancy and Growth Outcomes among HIV-Exposed Uninfected Infants in Kenya.
Infect Dis Obstet Gynecol
; 2015: 276851, 2015.
Article
in En
| MEDLINE
| ID: mdl-26823647
ABSTRACT
BACKGROUND:
Tenofovir disoproxil fumarate (TDF) is commonly used in antiretroviral treatment (ART) and preexposure prophylaxis regimens. We evaluated the relationship of prenatal TDF use and growth outcomes among Kenyan HIV-exposed uninfected (HEU) infants. MATERIALS ANDMETHODS:
We included PCR-confirmed HEU infants enrolled in a cross-sectional survey of mother-infant pairs conducted between July and December 2013 in Kenya. Maternal ART regimen during pregnancy was determined by self-report and clinic records. Six-week and 9-month z-scores for weight-for-age (WAZ), weight-for-length (WLZ), length-for-age (LAZ), and head circumference-for-age (HCAZ) were compared among HEU infants with and without TDF exposure using t-tests and multivariate linear regression models.RESULTS:
Among 277 mothers who received ART during pregnancy, 63% initiated ART before pregnancy, of which 89 (32%) used TDF. No differences in birth weight (3.0 kg versus 3.1 kg, p = 0.21) or gestational age (38 weeks versus 38 weeks, p = 0.16) were detected between TDF-exposed and TDF-unexposed infants. At 6 weeks, unadjusted mean WAZ was lower among TDF-exposed infants (-0.8 versus -0.4, p = 0.03), with a trend towards association in adjusted analyses (p = 0.06). There were no associations between prenatal TDF use and WLZ, LAZ, and HCAZ in 6-week or 9-month infant cohorts.CONCLUSION:
Maternal TDF use did not adversely affect infant growth compared to other regimens.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pregnancy Complications, Infectious
/
Birth Weight
/
HIV Infections
/
Infectious Disease Transmission, Vertical
/
Anti-HIV Agents
/
Tenofovir
Type of study:
Observational_studies
/
Prognostic_studies
Limits:
Adult
/
Female
/
Humans
/
Infant
/
Newborn
/
Pregnancy
Country/Region as subject:
Africa
Language:
En
Journal:
Infect Dis Obstet Gynecol
Journal subject:
DOENCAS TRANSMISSIVEIS
/
GINECOLOGIA
/
OBSTETRICIA
Year:
2015
Type:
Article
Affiliation country:
United States