Updated long-term survival for patients with metastatic colorectal cancer treated with liver resection followed by hepatic arterial infusion and systemic chemotherapy.
J Surg Oncol
; 113(5): 477-84, 2016 Apr.
Article
in En
| MEDLINE
| ID: mdl-26830685
ABSTRACT
BACKGROUND AND OBJECTIVES:
Patients who undergo liver resection for metastatic colorectal cancer (mCRC) have reported 5-year survivals ranging from 25% to 50%. The current study updated long-term survival for patients with resected liver metastases treated with adjuvant hepatic arterial infusion (HAI) and systemic (SYS) chemotherapy.METHODS:
Updated survival and recurrence free survival for patients treated on four consecutive adjuvant protocols with HAI and SYS from 1991 to 2009. Patients were divided into two groups those treated on protocols before 2003 and after 2003. Median follow-up for all patients was 11 years.RESULTS:
All 287 patients enrolled in four prospective protocols after liver resection are included. Patients treated before 2003 had a median follow-up of 15 years, 5 and 10-year survivals of 56% [95%CI 49-64%] and 40% [95%CI 32-47%], respectively, and median survival of 71 months. Patients treated after 2003 had a median follow-up of 9 years, 5 and 10-year survivals of 78% [95%CI 70-84%] and 61% [95%CI 51-70%], respectively, and median survival has not been reached.CONCLUSIONS:
Survival is improving for patients with mCRC who undergo liver resection. These data support the durability of long-term survival in patients who undergo resection followed by adjuvant HAI and SYS therapy. J. Surg. Oncol. 2016;113477-484. © 2016 Wiley Periodicals, Inc.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Camptothecin
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Colorectal Neoplasms
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Antineoplastic Combined Chemotherapy Protocols
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Hepatectomy
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Liver Neoplasms
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Antineoplastic Agents
Type of study:
Guideline
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limits:
Adult
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Aged
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Female
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Humans
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Male
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Middle aged
Language:
En
Journal:
J Surg Oncol
Year:
2016
Type:
Article