Preclinical Abuse Potential Assessment of Flibanserin: Effects on Intracranial Self-Stimulation in Female and Male Rats.

Lazenka, Matthew F; Blough, Bruce E; Negus, S Stevens

Lazenka, Matthew F; Blough, Bruce E; Negus, S Stevens.

Affiliation

Lazenka MF; Department of Pharmacology and Toxicology and Institute for Drug and Alcohol Studies, Virginia Commonwealth University, Richmond, VA, USA. Electronic address: lazenkamf@vcu.edu.
Blough BE; Center for Drug Discovery, Research Triangle Institute, Research Triangle Park, NC, USA.
Negus SS; Department of Pharmacology and Toxicology and Institute for Drug and Alcohol Studies, Virginia Commonwealth University, Richmond, VA, USA.

J Sex Med ; 13(3): 338-49, 2016 Mar.

Article in En | MEDLINE | ID: mdl-26831817

Subject(s)

Benzimidazoles/pharmacology; Brain/pathology; Self Stimulation/drug effects; Serotonin 5-HT2 Receptor Agonists/pharmacology; Serotonin 5-HT2 Receptor Antagonists/pharmacology; Substance-Related Disorders/pathology; Animals; Brain/drug effects; Conditioning, Operant/drug effects; Electric Stimulation; Female; Male; Medial Forebrain Bundle/drug effects; Medial Forebrain Bundle/pathology; Rats; Rats, Sprague-Dawley; United States

Key words

Drug Abuse; Female; Intracranial Self-Stimulation; Rat; Serotonin Receptor; Sex Differences

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Self Stimulation / Benzimidazoles / Brain / Substance-Related Disorders / Serotonin 5-HT2 Receptor Agonists / Serotonin 5-HT2 Receptor Antagonists Limits: Animals Country/Region as subject: America do norte Language: En Journal: J Sex Med Journal subject: GINECOLOGIA / MEDICINA REPRODUTIVA / UROLOGIA Year: 2016 Type: Article

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