Your browser doesn't support javascript.
loading
Tristetraprolin suppresses the EMT through the down-regulation of Twist1 and Snail1 in cancer cells.
Yoon, Nal Ae; Jo, Hyun Gun; Lee, Unn Hwa; Park, Ji Hye; Yoon, Ji Eun; Ryu, Jinhyun; Kang, Sang Soo; Min, Young Joo; Ju, Seong-A; Seo, Eun Hui; Huh, In Young; Lee, Byung Ju; Park, Jeong Woo; Cho, Wha Ja.
Affiliation
  • Yoon NA; Department of Biological Sciences, University of Ulsan, Ulsan 680-749, Korea.
  • Jo HG; Department of Biological Sciences, University of Ulsan, Ulsan 680-749, Korea.
  • Lee UH; Department of Biological Sciences, University of Ulsan, Ulsan 680-749, Korea.
  • Park JH; Department of Biological Sciences, University of Ulsan, Ulsan 680-749, Korea.
  • Yoon JE; Department of Biological Sciences, University of Ulsan, Ulsan 680-749, Korea.
  • Ryu J; Department of Anatomy and Convergence Medical Science, Institute of Health Sciences, School of Medicine, Gyeongsang National University, Jinju, Gyeongnam 52727, Korea.
  • Kang SS; Department of Anatomy and Convergence Medical Science, Institute of Health Sciences, School of Medicine, Gyeongsang National University, Jinju, Gyeongnam 52727, Korea.
  • Min YJ; Department of Internal Medicine, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan 682-060, Korea.
  • Ju SA; Biomedical Research Center, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan 682-060, Korea.
  • Seo EH; Department of Anesthesiology and Pain Medicine, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan 682-060, Korea.
  • Huh IY; Department of Anesthesiology and Pain Medicine, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan 682-060, Korea.
  • Lee BJ; Department of Biological Sciences, University of Ulsan, Ulsan 680-749, Korea.
  • Park JW; Department of Biological Sciences, University of Ulsan, Ulsan 680-749, Korea.
  • Cho WJ; Biomedical Research Center, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan 682-060, Korea.
Oncotarget ; 7(8): 8931-43, 2016 Feb 23.
Article in En | MEDLINE | ID: mdl-26840564
ABSTRACT
Inhibition of epithelial-mesenchymal transition (EMT)-inducing transcription factors Twist and Snail prevents tumor metastasis but enhances metastatic growth. Here, we report an unexpected role of a tumor suppressor tristetraprolin (TTP) in inhibiting Twist and Snail without enhancing cellular proliferation. TTP bound to the AU-rich element (ARE) within the mRNA 3'UTRs of Twist1 and Snail1, enhanced the decay of their mRNAs and inhibited the EMT of cancer cells. The ectopic expression of Twist1 or Snail1 without their 3'UTRs blocked the inhibitory effects of TTP on the EMT. We also observed that TTP overexpression suppressed the growth of cancer cells. Our data propose a new model whereby TTP down-regulates Twist1 and Snail1 and inhibits both the EMT and the proliferation of cancer cells.
Subject(s)
Key words
Fulltext
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Nuclear Proteins / Gene Expression Regulation, Neoplastic / Twist-Related Protein 1 / Tristetraprolin / Epithelial-Mesenchymal Transition / Snail Family Transcription Factors / Neoplasms Type of study: Prognostic_studies Limits: Humans Language: En Journal: Oncotarget Year: 2016 Type: Article
Fulltext
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Nuclear Proteins / Gene Expression Regulation, Neoplastic / Twist-Related Protein 1 / Tristetraprolin / Epithelial-Mesenchymal Transition / Snail Family Transcription Factors / Neoplasms Type of study: Prognostic_studies Limits: Humans Language: En Journal: Oncotarget Year: 2016 Type: Article