Screening of lipase inhibitors from Scutellaria baicalensis extract using lipase immobilized on magnetic nanoparticles and study on the inhibitory mechanism.

Wan, Li-Hong; Jiang, Xiao-Lan; Liu, Yi-Ming; Hu, Jin-Jie; Liang, Jian; Liao, Xun

Wan, Li-Hong; Jiang, Xiao-Lan; Liu, Yi-Ming; Hu, Jin-Jie; Liang, Jian; Liao, Xun.

Affiliation

Wan LH; Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu, 610041, China.
Jiang XL; University of Chinese Academy of Sciences, Beijing, 100049, China.
Liu YM; Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu, 610041, China.
Hu JJ; University of Chinese Academy of Sciences, Beijing, 100049, China.
Liang J; Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu, 610041, China. yiming.liu@jsums.edu.
Liao X; Department of Chemistry and Biochemistry, Jackson State University, 1400 Lynch St., Jackson, MS, 39217, USA. yiming.liu@jsums.edu.

Anal Bioanal Chem ; 408(9): 2275-83, 2016 Mar.

Article in En | MEDLINE | ID: mdl-26873215

Subject(s)

Enzyme Inhibitors/analysis; Enzymes, Immobilized/chemistry; Lipase/antagonists & inhibitors; Magnetics; Nanoparticles; Plant Extracts/chemistry; Scutellaria baicalensis/chemistry; Chromatography, High Pressure Liquid; Enzyme Inhibitors/isolation & purification; Microscopy, Electron, Transmission; Spectroscopy, Fourier Transform Infrared; Tandem Mass Spectrometry; Thermogravimetry

Key words

Fluorescence spectroscopy; Lipase inhibitors; Magnetic solid phase extraction; Molecular docking; Scutellaria baicalensis

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Plant Extracts / Scutellaria baicalensis / Enzyme Inhibitors / Enzymes, Immobilized / Nanoparticles / Lipase / Magnetics Type of study: Diagnostic_studies / Screening_studies Language: En Journal: Anal Bioanal Chem Year: 2016 Type: Article Affiliation country: China

Fulltext

XML

PubMed Links

Search on Google