The role of the antioxidant ascorbic acid in the elicitation of contact allergic reactions to p-phenylenediamine.
Contact Dermatitis
; 74(5): 267-72, 2016 May.
Article
in En
| MEDLINE
| ID: mdl-26875881
ABSTRACT
BACKGROUND:
An allergic contact reaction is accompanied by high oxidative stress in the skin. Pretreatment of the skin with antioxidative substances could reduce the elicitation reaction.OBJECTIVES:
To investigate, in a proof-of-principle study, whether pretreatment of the skin with the antioxidant ascorbic acid reduces the elicitation reaction to a p-phenylenediamine (PPD)-containing hair dye in sensitized subjects.METHODS:
Twelve subjects with contact allergy to PPD, a documented skin reaction to a hair dye simulation exposure model and a history of hair dye-related skin complaints were included in this study. Skin areas on the forearms were, in a left versus right design, exposed to an emulsion with ascorbic acid and an emulsion without ascorbic acid, and then to a 2% PPD-containing hair dye testing formulation. In addition, control areas were exposed to the emulsions and to the PPD-containing hair dye formulation without pretreatment. Skin reactions were graded on day (D)2 and D3.RESULTS:
Pretreatment with ascorbic acid emulsion resulted in a reduction in the elicitation reaction in 7 of 12 subjects at D3 (p = 0.046). No statistically significant difference was observed at D2.CONCLUSIONS:
Pretreatment of the skin with the antioxidant ascorbic acid had an attenuating effect on the elicitation reaction to PPD in sensitized individuals.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Phenylenediamines
/
Premedication
/
Ascorbic Acid
/
Skin
/
Patch Tests
/
Dermatitis, Allergic Contact
/
Coloring Agents
/
Antioxidants
Type of study:
Etiology_studies
/
Prognostic_studies
Limits:
Adolescent
/
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Contact Dermatitis
Year:
2016
Type:
Article
Affiliation country:
Netherlands