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Efficacy of Azacitidine in autoimmune and inflammatory disorders associated with myelodysplastic syndromes and chronic myelomonocytic leukemia.
Fraison, Jean-Baptiste; Mekinian, Arsène; Grignano, Eric; Kahn, Jean-Emmanuel; Arlet, Jean-Benoit; Decaux, Olivier; Denis, Guillaume; Buchdahl, Anne-Laure; Omouri, Mohamed; Maigne, Gwenola; Aouba, Achille; Leon, Nathalie; Berthier, Sabine; Liozon, Eric; Park, Sophie; Gardin, Claude; Lortholary, Olivier; Rossignol, Julien; Fenaux, Pierre; Fain, Olivier; Braun, Thorsten.
Affiliation
  • Fraison JB; Service de Médecine Interne, Hôpital Jean Verdier, Assistance Publique des Hôpitaux de Paris, Université Paris XIII, France. Electronic address: jeanbaptiste.fraison@aphp.fr.
  • Mekinian A; Service de Médecine Interne, DHU i2B, Inflammation-Immunopathologie-Biothérapie (DHU i2B), Hôpital Saint Antoine, Assistance Publique des Hôpitaux de Paris, Université Paris VI Sorbonne, 75012 Paris, France.
  • Grignano E; Service d'hématologie, Institut de Cancérologie Gustave Roussy, 94800 Villejuif, France.
  • Kahn JE; Service de Médecine Interne, Hôpital Foch, Suresnes, France.
  • Arlet JB; Service de Médecine Interne, Hôpital Européen Georges Pompidoux, Université Paris V, Paris, France.
  • Decaux O; Service de Médecine Interne, Centre Hospitalier Universitaire de Rennes, France.
  • Denis G; Service de Médecine Interne, Centre Hospitalier de Rochefort, France.
  • Buchdahl AL; Service de Médecine Interne, Centre Hospitalier de Douai, France.
  • Omouri M; Service de Rhumatologie, Centre Hospitalier de Romilly, France.
  • Maigne G; Service de Médecine Interne, Centre Hospitalier Universitaire de Caen, France.
  • Aouba A; Service de Médecine Interne, Centre Hospitalier Universitaire de Caen, France.
  • Leon N; Service de Rhumatologie, Centre Hospitalier Universitaire de Caen, France.
  • Berthier S; Service de Médecine Interne, Centre Hospitalier Universitaire de Dijon, France.
  • Liozon E; Service de Médecine Interne, Centre Hospitalier Universitaire de Limoges, France.
  • Park S; Service d'Hématologie, Centre Hospitalier Universitaire de Grenoble, France.
  • Gardin C; Service d'Hématologie, Hôpital Avicenne, Université Paris XIII, Bobigny, France.
  • Lortholary O; Service de Maladies Infectieuses, Hôpital Necker, Université Paris V, Paris, France.
  • Rossignol J; Service d'hématologie, Institut de Cancérologie Gustave Roussy, 94800 Villejuif, France.
  • Fenaux P; Service d'Hématologie, Hôpital Saint Louis, Université Paris VII, Paris, France.
  • Fain O; Service de Médecine Interne, DHU i2B, Inflammation-Immunopathologie-Biothérapie (DHU i2B), Hôpital Saint Antoine, Assistance Publique des Hôpitaux de Paris, Université Paris VI Sorbonne, 75012 Paris, France.
  • Braun T; Service d'Hématologie, Hôpital Avicenne, Université Paris XIII, Bobigny, France.
Leuk Res ; 43: 13-7, 2016 Apr.
Article in En | MEDLINE | ID: mdl-26922775
ABSTRACT
This retrospective study describes efficacy of Azacitidine on autoimmune disorders (AID) associated with MDS/CMML in 22 patients. Response of AID to Azacitidine was observed in 19 patients (86%). Reduction or discontinuation of steroids and/or immunosuppressive therapy (IST) was possible in 16 cases (73%). Hematologic response was seen in 55% of the patients. MDS/CMML and AID evolution was concordant in 13 cases (59%) both favorable (n=11), both unfavorable (n=2), but AID improved while MDS/CMML worsened (n=8) and vice versa (n=1). Azacitidine frequently seems effective in controlling steroid-dependent AID associated with MDS/CMML, but prospective studies are necessary to confirm those findings.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Autoimmune Diseases / Azacitidine / Myelodysplastic Syndromes / Leukemia, Myelogenous, Chronic, BCR-ABL Positive Type of study: Observational_studies / Risk_factors_studies Limits: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Language: En Journal: Leuk Res Year: 2016 Type: Article
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Autoimmune Diseases / Azacitidine / Myelodysplastic Syndromes / Leukemia, Myelogenous, Chronic, BCR-ABL Positive Type of study: Observational_studies / Risk_factors_studies Limits: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Language: En Journal: Leuk Res Year: 2016 Type: Article