Your browser doesn't support javascript.
loading
Comparing isogenic strains of Beijing genotype Mycobacterium tuberculosis after acquisition of Isoniazid resistance: A proteomics approach.
Nieto R, Luisa María; Mehaffy, Carolina; Dobos, Karen M.
Affiliation
  • Nieto R LM; Department of Microbiology, Immunology and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO, USA.
  • Mehaffy C; Department of Microbiology, Immunology and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO, USA.
  • Dobos KM; Department of Microbiology, Immunology and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO, USA.
Proteomics ; 16(9): 1376-80, 2016 05.
Article in En | MEDLINE | ID: mdl-26929115
We determined differences in the protein abundance among two isogenic strains of Mycobacterium tuberculosis (Mtb) with different Isoniazid (INH) susceptibility profiles. The strains were isolated from a pulmonary tuberculosis patient before and after drug treatment. LC-MS/MS analysis identified 46 Mtb proteins with altered abundance after INH resistance acquisition. Protein abundance comparisons were done evaluating the different bacterial cellular fractions (membrane, cytosol, cell wall and secreted proteins). MS data have been deposited to the ProteomeXchange with identifier PXD002986.
Subject(s)
Key words
Fulltext
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Gene Expression Regulation, Bacterial / Drug Resistance, Bacterial / Isoniazid / Mycobacterium tuberculosis / Antitubercular Agents Limits: Humans Language: En Journal: Proteomics Journal subject: BIOQUIMICA Year: 2016 Type: Article Affiliation country: United States
Fulltext
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Gene Expression Regulation, Bacterial / Drug Resistance, Bacterial / Isoniazid / Mycobacterium tuberculosis / Antitubercular Agents Limits: Humans Language: En Journal: Proteomics Journal subject: BIOQUIMICA Year: 2016 Type: Article Affiliation country: United States