Depolarization of mitochondria in neurons promotes activation of nitric oxide synthase and generation of nitric oxide.

Katakam, Prasad V G; Dutta, Somhrita; Sure, Venkata N; Grovenburg, Samuel M; Gordon, Angellica O; Peterson, Nicholas R; Rutkai, Ibolya; Busija, David W

Katakam, Prasad V G; Dutta, Somhrita; Sure, Venkata N; Grovenburg, Samuel M; Gordon, Angellica O; Peterson, Nicholas R; Rutkai, Ibolya; Busija, David W.

Affiliation

Katakam PV; Department of Pharmacology, Tulane University School of Medicine, Tulane University, New Orleans, Louisiana pkatakam@tulane.edu.
Dutta S; Department of Pharmacology, Tulane University School of Medicine, Tulane University, New Orleans, Louisiana.
Sure VN; Department of Pharmacology, Tulane University School of Medicine, Tulane University, New Orleans, Louisiana.
Grovenburg SM; Department of Pharmacology, Tulane University School of Medicine, Tulane University, New Orleans, Louisiana.
Gordon AO; Department of Pharmacology, Tulane University School of Medicine, Tulane University, New Orleans, Louisiana.
Peterson NR; Department of Pharmacology, Tulane University School of Medicine, Tulane University, New Orleans, Louisiana.
Rutkai I; Department of Pharmacology, Tulane University School of Medicine, Tulane University, New Orleans, Louisiana.
Busija DW; Department of Pharmacology, Tulane University School of Medicine, Tulane University, New Orleans, Louisiana.

Am J Physiol Heart Circ Physiol ; 310(9): H1097-106, 2016 05 01.

Article in En | MEDLINE | ID: mdl-26945078

Subject(s)

Cerebral Arteries/metabolism; Membrane Potential, Mitochondrial; Mitochondria/enzymology; Nitrergic Neurons/enzymology; Nitric Oxide Synthase Type I/metabolism; Nitric Oxide/metabolism; Paracrine Communication; Vasodilation; Animals; Benzopyrans/pharmacology; Cells, Cultured; Cerebral Arteries/drug effects; Cerebral Arteries/innervation; Diazoxide/pharmacology; Enzyme Activation; Enzyme Inhibitors/pharmacology; Imidazoles/pharmacology; Indazoles/pharmacology; Male; Membrane Potential, Mitochondrial/drug effects; Mitochondria/drug effects; Nitrergic Neurons/drug effects; Nitric Oxide Synthase Type I/antagonists & inhibitors; Paracrine Communication/drug effects; Phosphorylation; Potassium Channels/agonists; Potassium Channels/metabolism; Primary Cell Culture; Rats, Sprague-Dawley; Reactive Oxygen Species/metabolism; Serine; Signal Transduction; Vasodilation/drug effects

Key words

BMS-191095; diazoxide; membrane potential; mitochondrial ATP-sensitive potassium channels; superoxide anion

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Vasodilation / Cerebral Arteries / Paracrine Communication / Nitrergic Neurons / Nitric Oxide Synthase Type I / Membrane Potential, Mitochondrial / Mitochondria / Nitric Oxide Limits: Animals Language: En Journal: Am J Physiol Heart Circ Physiol Journal subject: CARDIOLOGIA / FISIOLOGIA Year: 2016 Type: Article

Fulltext

XML

PubMed Links

Search on Google