Effects of sodium selenite on c-Jun N-terminal kinase signalling pathway induced by oxidative stress in human chondrocytes and c-Jun N-terminal kinase expression in patients with Kashin-Beck disease, an endemic osteoarthritis.

Dai, XiaoXia; Li, YuanYuan; Zhang, RongQiang; Kou, Yan; Mo, XiaoYan; Cao, JunLing; Xiong, YongMin

Dai, XiaoXia; Li, YuanYuan; Zhang, RongQiang; Kou, Yan; Mo, XiaoYan; Cao, JunLing; Xiong, YongMin.

Affiliation

Dai X; 1Key Laboratory of Environment and Genes Related to Diseases of Education Ministry,Health Science Center,Institute of Endemic Diseases,Xi'an Jiaotong University,No.76 Yanta West Road,Xi'an,Shaanxi 710061,People's Republic of China.
Li Y; 2School of Life Science and Technology,Xi'an Jiaotong University,Xi'an,Shaanxi 710049,People's Republic of China.
Zhang R; 1Key Laboratory of Environment and Genes Related to Diseases of Education Ministry,Health Science Center,Institute of Endemic Diseases,Xi'an Jiaotong University,No.76 Yanta West Road,Xi'an,Shaanxi 710061,People's Republic of China.
Kou Y; 2School of Life Science and Technology,Xi'an Jiaotong University,Xi'an,Shaanxi 710049,People's Republic of China.
Mo X; 2School of Life Science and Technology,Xi'an Jiaotong University,Xi'an,Shaanxi 710049,People's Republic of China.
Cao J; 1Key Laboratory of Environment and Genes Related to Diseases of Education Ministry,Health Science Center,Institute of Endemic Diseases,Xi'an Jiaotong University,No.76 Yanta West Road,Xi'an,Shaanxi 710061,People's Republic of China.
Xiong Y; 1Key Laboratory of Environment and Genes Related to Diseases of Education Ministry,Health Science Center,Institute of Endemic Diseases,Xi'an Jiaotong University,No.76 Yanta West Road,Xi'an,Shaanxi 710061,People's Republic of China.

Br J Nutr ; 115(9): 1547-55, 2016 05.

Article in En | MEDLINE | ID: mdl-26948765

Subject(s)

Chondrocytes/drug effects; JNK Mitogen-Activated Protein Kinases/metabolism; Kashin-Beck Disease/metabolism; MAP Kinase Signaling System; Osteoarthritis/metabolism; Oxidative Stress/drug effects; Sodium Selenite/pharmacology; Antioxidants/metabolism; Antioxidants/pharmacology; Apoptosis/drug effects; Cell Survival/drug effects; Chondrocytes/metabolism; Down-Regulation; Glutathione Peroxidase/metabolism; Humans; Phosphorylation; Reactive Oxygen Species/metabolism; Selenium/pharmacology; Signal Transduction; Up-Regulation; tert-Butylhydroperoxide

Key words

ATF2 activating transcription factor 2; Apoptosis; Bcl-2 B-cell lymphoma 2 (Bcl-2); Chondrocytes; GPx glutathione peroxidase; JNK c-Jun N-terminal kinase; KBD KashinBeck disease; KashinBeck disease; MEKK1 mitogen-activated protein kinase kinase kinase 1; MTT methylthiazolyl tetrazolium; OA osteoarthritis; RA rheumatoid arthritis; ROS reactive oxygen species; Selenium; c-Jun N-terminal kinases signalling pathway; tBHP tert-butyl hydroperoxide

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Osteoarthritis / Sodium Selenite / Oxidative Stress / Chondrocytes / MAP Kinase Signaling System / JNK Mitogen-Activated Protein Kinases / Kashin-Beck Disease Type of study: Prognostic_studies Limits: Humans Language: En Journal: Br J Nutr Year: 2016 Type: Article

Fulltext

XML

PubMed Links

Search on Google