The current state of the art of quantitative phosphoproteomics and its applications to diabetes research.
Expert Rev Proteomics
; 13(4): 421-33, 2016.
Article
in En
| MEDLINE
| ID: mdl-26960075
ABSTRACT
Protein phosphorylation is a fundamental regulatory mechanism in many cellular processes and aberrant perturbation of phosphorylation has been implicated in various human diseases. Kinases and their cognate inhibitors have been considered as hotspots for drug development. Therefore, the emerging tools, which enable a system-wide quantitative profiling of phosphoproteome, would offer a powerful impetus in unveiling novel signaling pathways, drug targets and/or biomarkers for diseases of interest. This review highlights recent advances in phosphoproteomics, the current state of the art of the technologies and the challenges and future perspectives of this research area. Finally, some exemplary applications of phosphoproteomics in diabetes research are underscored.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Protein Processing, Post-Translational
/
Proteome
/
Proteomics
/
Diabetes Mellitus
Limits:
Animals
/
Humans
Language:
En
Journal:
Expert Rev Proteomics
Journal subject:
BIOQUIMICA
Year:
2016
Type:
Article
Affiliation country:
United States