Cutaneous T-cell Lymphoma and Pruritus: The Expression of IL-31 and its Receptors in the Skin.
Acta Derm Venereol
; 96(7): 894-898, 2016 Nov 02.
Article
in En
| MEDLINE
| ID: mdl-27001482
ABSTRACT
Approximately 88% of cutaneous T-cell lymphoma (CTCL) patients are affected by pruritus that responds poorly to current antipruritic therapies. Interleukin (IL)-31, a Th2 cytokine, has been found to be increased in the serum of CTCL patients and to correlate with itch severity. This study investigated the role of IL-31 and its receptors (IL-31 receptor-alpha [IL-31RA] and OSMRß) in the skin of CTCL patients with mild versus moderate/severe pruritus. Expression levels of IL-31, IL-31RA, and OSMRß in the skin were measured using immunohistochemistry and correlated to pruritus severity and disease stage. In CTCL patients with moderate/severe pruritus, IL-31 was significantly elevated in the epidermis and dermal infiltrate, while IL-31RA and OSMRß were significantly elevated only in the epidermis. Furthermore, epidermal IL-31 levels correlated to itch severity. These results show that IL-31 may play a role in CTCL pruritus by exerting indirect effects on sensory nerves through epidermal neoplastic T cells and keratinocytes to transmit itch.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pruritus
/
Lymphoma, T-Cell, Cutaneous
/
Interleukins
/
Receptors, Interleukin
/
Oncostatin M Receptor beta Subunit
Limits:
Aged
/
Female
/
Humans
/
Male
Language:
En
Journal:
Acta Derm Venereol
Year:
2016
Type:
Article
Affiliation country:
United States