A1 adenosine receptor-induced phosphorylation and modulation of transglutaminase 2 activity in H9c2 cells: A role in cell survival.

Vyas, Falguni S; Hargreaves, Alan J; Bonner, Philip L R; Boocock, David J; Coveney, Clare; Dickenson, John M

Vyas, Falguni S; Hargreaves, Alan J; Bonner, Philip L R; Boocock, David J; Coveney, Clare; Dickenson, John M.

Affiliation

Vyas FS; School of Science and Technology, Nottingham Trent University, Clifton Lane, Nottingham NG11 8NS, United Kingdom.
Hargreaves AJ; School of Science and Technology, Nottingham Trent University, Clifton Lane, Nottingham NG11 8NS, United Kingdom.
Bonner PL; School of Science and Technology, Nottingham Trent University, Clifton Lane, Nottingham NG11 8NS, United Kingdom.
Boocock DJ; John van Geest Cancer Research Centre, Nottingham Trent University, Clifton Lane, Nottingham NG11 8NS, United Kingdom.
Coveney C; John van Geest Cancer Research Centre, Nottingham Trent University, Clifton Lane, Nottingham NG11 8NS, United Kingdom.
Dickenson JM; School of Science and Technology, Nottingham Trent University, Clifton Lane, Nottingham NG11 8NS, United Kingdom. Electronic address: john.dickenson@ntu.ac.uk.

Biochem Pharmacol ; 107: 41-58, 2016 May 01.

Article in En | MEDLINE | ID: mdl-27005940

Subject(s)

Adenosine A1 Receptor Agonists/pharmacology; GTP-Binding Proteins/agonists; MAP Kinase Signaling System/drug effects; Myoblasts, Cardiac/drug effects; Protein Processing, Post-Translational/drug effects; Receptor, Adenosine A1/metabolism; Adenosine/analogs & derivatives; Adenosine/pharmacology; Animals; Calcium Signaling/drug effects; Cell Hypoxia/drug effects; Cell Line; Cell Survival/drug effects; Enzyme Inhibitors/pharmacology; GTP-Binding Proteins/antagonists & inhibitors; GTP-Binding Proteins/metabolism; Hexokinase/metabolism; Histones/metabolism; Kinetics; Myoblasts, Cardiac/cytology; Myoblasts, Cardiac/metabolism; Phosphorylation/drug effects; Protein Glutamine gamma Glutamyltransferase 2; Protein Kinase Inhibitors/pharmacology; Rats; Receptor, Adenosine A1/blood; Substrate Specificity; Transglutaminases/antagonists & inhibitors; Transglutaminases/metabolism

Key words

A(1) adenosine receptor; Cytoprotection; G protein-coupled receptor; SWATH mass spectrometry; Transglutaminase 2

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Protein Processing, Post-Translational / GTP-Binding Proteins / MAP Kinase Signaling System / Myoblasts, Cardiac / Receptor, Adenosine A1 / Adenosine A1 Receptor Agonists Limits: Animals Language: En Journal: Biochem Pharmacol Year: 2016 Type: Article Affiliation country: United kingdom

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