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Survey of variation in human transcription factors reveals prevalent DNA binding changes.
Barrera, Luis A; Vedenko, Anastasia; Kurland, Jesse V; Rogers, Julia M; Gisselbrecht, Stephen S; Rossin, Elizabeth J; Woodard, Jaie; Mariani, Luca; Kock, Kian Hong; Inukai, Sachi; Siggers, Trevor; Shokri, Leila; Gordân, Raluca; Sahni, Nidhi; Cotsapas, Chris; Hao, Tong; Yi, Song; Kellis, Manolis; Daly, Mark J; Vidal, Marc; Hill, David E; Bulyk, Martha L.
Affiliation
  • Barrera LA; Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
  • Vedenko A; Committee on Higher Degrees in Biophysics, Harvard University, Cambridge, MA 02138, USA.
  • Kurland JV; Harvard-MIT Division of Health Sciences and Technology, Harvard Medical School, Boston, MA 02115, USA.
  • Rogers JM; Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
  • Gisselbrecht SS; Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
  • Rossin EJ; Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
  • Woodard J; Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
  • Mariani L; Committee on Higher Degrees in Biophysics, Harvard University, Cambridge, MA 02138, USA.
  • Kock KH; Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
  • Inukai S; Harvard-MIT Division of Health Sciences and Technology, Harvard Medical School, Boston, MA 02115, USA.
  • Siggers T; Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
  • Shokri L; Broad Institute of Harvard and MIT, Cambridge, MA 02139, USA.
  • Gordân R; Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
  • Sahni N; Committee on Higher Degrees in Biophysics, Harvard University, Cambridge, MA 02138, USA.
  • Cotsapas C; Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
  • Hao T; Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
  • Yi S; Program in Biological and Biomedical Sciences, Harvard University, Cambridge, MA 02138, USA.
  • Kellis M; Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
  • Daly MJ; Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
  • Vidal M; Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
  • Hill DE; Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
  • Bulyk ML; Center for Cancer Systems Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
Science ; 351(6280): 1450-1454, 2016 Mar 25.
Article in En | MEDLINE | ID: mdl-27013732
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Transcription Factors / DNA / Gene Expression Regulation / DNA-Binding Proteins / Genetic Diseases, Inborn Type of study: Prognostic_studies Limits: Humans Language: En Journal: Science Year: 2016 Type: Article Affiliation country: United States
Fulltext
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Transcription Factors / DNA / Gene Expression Regulation / DNA-Binding Proteins / Genetic Diseases, Inborn Type of study: Prognostic_studies Limits: Humans Language: En Journal: Science Year: 2016 Type: Article Affiliation country: United States