Overexpression of Lin28b in Neural Stem Cells is Insufficient for Brain Tumor Formation, but Induces Pathological Lobulation of the Developing Cerebellum.

Wefers, Annika K; Lindner, Sven; Schulte, Johannes H; Schüller, Ulrich

Wefers, Annika K; Lindner, Sven; Schulte, Johannes H; Schüller, Ulrich.

Affiliation

Wefers AK; Center for Neuropathology, Ludwig-Maximilians-University, Feodor-Lynen-Strasse 23, D-81377, Munich, Germany.
Lindner S; Department of Neuropathology, Institute of Pathology, Ruprecht-Karls-University Heidelberg, Heidelberg, Germany.
Schulte JH; Department of Pediatric Oncology and Hematology, University Hospital Essen, Essen, Germany.
Schüller U; Department of Pediatric Oncology and Hematology, University Hospital Essen, Essen, Germany.

Cerebellum ; 16(1): 122-131, 2017 02.

Article in En | MEDLINE | ID: mdl-27039094

Subject(s)

Cerebellum/abnormalities; Cerebellum/growth & development; DNA-Binding Proteins/metabolism; Neural Stem Cells/metabolism; Neurons/metabolism; Animals; Brain Neoplasms/metabolism; Carcinogenesis/metabolism; Cerebellum/metabolism; DNA-Binding Proteins/genetics; Immunohistochemistry; Mice, 129 Strain; Mice, Inbred C57BL; Mice, Transgenic; Nerve Tissue Proteins/metabolism; Nestin/metabolism; Neural Stem Cells/pathology; Neurons/pathology; Nuclear Proteins/metabolism; PAX2 Transcription Factor/metabolism; PAX6 Transcription Factor/metabolism; Phenotype; RNA-Binding Proteins

Key words

Cerebellum; Development; Hypersublobulation; LIN28B; Nestin; Tumor

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cerebellum / DNA-Binding Proteins / Neural Stem Cells / Neurons Limits: Animals Language: En Journal: Cerebellum Journal subject: CEREBRO Year: 2017 Type: Article Affiliation country: Germany

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