Changes in Course of Retinopathy of Prematurity from 1986 to 2013: Comparison of Three Studies in the United States.
Ophthalmology
; 123(7): 1595-600, 2016 07.
Article
in En
| MEDLINE
| ID: mdl-27084562
ABSTRACT
PURPOSE:
To compare infant and retinopathy of prematurity (ROP) characteristics from 3 clinical studies conducted over a 27-year period in the United States.DESIGN:
Secondary analysis of results of 3 clinical studies.PARTICIPANTS:
Infants with birth weight (BW) <1251 g.METHODS:
Analysis of data from the Cryotherapy for Retinopathy of Prematurity (CRYO-ROP) and Early Treatment for Retinopathy of Prematurity (ETROP) trials and the primary data from the Telemedicine Approaches for the Evaluation of Acute-Phase Retinopathy of Prematurity (e-ROP) study. MAIN OUTCOMEMEASURES:
Infant characteristics and onset, severity, and time course of ROP.RESULTS:
Across the 3 studies, mean (standard deviation) BW and mean gestational age (GA) decreased over time from CRYO-ROP (954 g [185 g], 27.9 weeks [2.2 weeks]) to ETROP (907 g [205 g], 27.4 weeks [2.2 weeks]) to e-ROP (864 g [212 g], 27.0 weeks [2.2 weeks]), with an increase in the percentage of infants enrolled weighing <750 g (15.8% CRYO, 24.9% ETROP, 33.4% e-ROP; P<0.0001). The percentage of infants who developed ROP varied only minimally (65.8% CRYO, 68.0% ETROP, 63.7% e-ROP; P = 0.003). Moderately severe ROP (defined as prethreshold or referral warranted) varied (17.8% CRYO, 12.3% ETROP, 19.4% e-ROP; P<0.0001), whereas the time of onset of any ROP did not vary (34.3 weeks CRYO, 34.1 weeks ETROP, 34.8 weeks e-ROP).CONCLUSIONS:
The BW and GA of infants enrolled in ROP studies in the United States have decreased over the past 27 years, whereas ROP prevalence and onset of disease are stable.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Retinopathy of Prematurity
Type of study:
Etiology_studies
/
Prevalence_studies
/
Risk_factors_studies
Limits:
Female
/
Humans
/
Infant
/
Male
/
Newborn
Country/Region as subject:
America do norte
Language:
En
Journal:
Ophthalmology
Year:
2016
Type:
Article