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Discovery of 6-(Fluoro-(18)F)-3-(1H-pyrrolo[2,3-c]pyridin-1-yl)isoquinolin-5-amine ([(18)F]-MK-6240): A Positron Emission Tomography (PET) Imaging Agent for Quantification of Neurofibrillary Tangles (NFTs).
Walji, Abbas M; Hostetler, Eric D; Selnick, Harold; Zeng, Zhizhen; Miller, Patricia; Bennacef, Idriss; Salinas, Cristian; Connolly, Brett; Gantert, Liza; Holahan, Marie; O'Malley, Stacey; Purcell, Mona; Riffel, Kerry; Li, Jing; Balsells, Jaume; OBrien, Julie A; Melquist, Stacey; Soriano, Aileen; Zhang, Xiaoping; Ogawa, Aimie; Xu, Serena; Joshi, Elizabeth; Della Rocca, Joseph; Hess, Fred J; Schachter, Joel; Hesk, David; Schenk, David; Struyk, Arie; Babaoglu, Kerim; Lohith, Talakad G; Wang, Yaode; Yang, Kun; Fu, Jianmin; Evelhoch, Jeffrey L; Coleman, Paul J.
Affiliation
  • Walji AM; Discovery Chemistry, Merck & Co., Inc. , West Point Pennsylvania 19486, United States.
  • Hostetler ED; Imaging, Merck & Co., Inc. , West Point Pennsylvania 19486, United States.
  • Selnick H; Discovery Chemistry, Merck & Co., Inc. , West Point Pennsylvania 19486, United States.
  • Zeng Z; Imaging, Merck & Co., Inc. , West Point Pennsylvania 19486, United States.
  • Miller P; Imaging, Merck & Co., Inc. , West Point Pennsylvania 19486, United States.
  • Bennacef I; Imaging, Merck & Co., Inc. , West Point Pennsylvania 19486, United States.
  • Salinas C; Imaging, Merck & Co., Inc. , West Point Pennsylvania 19486, United States.
  • Connolly B; Imaging, Merck & Co., Inc. , West Point Pennsylvania 19486, United States.
  • Gantert L; Imaging, Merck & Co., Inc. , West Point Pennsylvania 19486, United States.
  • Holahan M; Imaging, Merck & Co., Inc. , West Point Pennsylvania 19486, United States.
  • O'Malley S; Imaging, Merck & Co., Inc. , West Point Pennsylvania 19486, United States.
  • Purcell M; Imaging, Merck & Co., Inc. , West Point Pennsylvania 19486, United States.
  • Riffel K; Imaging, Merck & Co., Inc. , West Point Pennsylvania 19486, United States.
  • Li J; Process Chemistry, Merck & Co., Inc. , West Point Pennsylvania 19486, United States.
  • Balsells J; Process Chemistry, Merck & Co., Inc. , West Point Pennsylvania 19486, United States.
  • OBrien JA; Pharmacology, Merck & Co., Inc. , West Point Pennsylvania 19486, United States.
  • Melquist S; Pharmacology, Merck & Co., Inc. , West Point Pennsylvania 19486, United States.
  • Soriano A; Pharmacology, Merck & Co., Inc. , Kenilworth, New Jersey 07033, United States.
  • Zhang X; Pharmacology, Merck & Co., Inc. , Kenilworth, New Jersey 07033, United States.
  • Ogawa A; Pharmacology, Merck & Co., Inc. , Kenilworth, New Jersey 07033, United States.
  • Xu S; Pharmacology, Merck & Co., Inc. , Kenilworth, New Jersey 07033, United States.
  • Joshi E; Drug Metabolism, Merck & Co., Inc. , West Point, Pennsylvania 19486, United States.
  • Della Rocca J; Discovery Pharmaceutical Sciences, Merck & Co., Inc. , West Point, Pennsylvania 19486, United States.
  • Hess FJ; Neuroscience, Merck & Co., Inc. , West Point, Pennsylvania 19486, United States.
  • Schachter J; Neuroscience, Merck & Co., Inc. , West Point, Pennsylvania 19486, United States.
  • Hesk D; Labelled Compound Synthesis, Merck & Co., Inc. , Rahway, New Jersey, 07065, United States.
  • Schenk D; Labelled Compound Synthesis, Merck & Co., Inc. , Rahway, New Jersey, 07065, United States.
  • Struyk A; Clinical Pharmacology, Merck & Co., Inc. , West Point, Pennsylvania 19486, United States.
  • Babaoglu K; Computational Chemistry, Merck & Co., Inc. , West Point, Pennsylvania 19486, United States.
  • Lohith TG; Imaging, Merck & Co., Inc. , West Point Pennsylvania 19486, United States.
  • Wang Y; Pharmaron Beijing Co., Ltd. , Beijing 100176, China.
  • Yang K; Pharmaron Beijing Co., Ltd. , Beijing 100176, China.
  • Fu J; Pharmaron Beijing Co., Ltd. , Beijing 100176, China.
  • Evelhoch JL; Imaging, Merck & Co., Inc. , West Point Pennsylvania 19486, United States.
  • Coleman PJ; Discovery Chemistry, Merck & Co., Inc. , West Point Pennsylvania 19486, United States.
J Med Chem ; 59(10): 4778-89, 2016 05 26.
Article in En | MEDLINE | ID: mdl-27088900
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Neurofibrillary Tangles / Positron-Emission Tomography / Drug Discovery / Molecular Imaging / Isoquinolines Limits: Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2016 Type: Article Affiliation country: United States
Fulltext
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Neurofibrillary Tangles / Positron-Emission Tomography / Drug Discovery / Molecular Imaging / Isoquinolines Limits: Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2016 Type: Article Affiliation country: United States