The EZH1-SUZ12 complex positively regulates the transcription of NF-&#954;B target genes through interaction with UXT.

Su, Shuai-Kun; Li, Chun-Yuan; Lei, Pin-Ji; Wang, Xiang; Zhao, Quan-Yi; Cai, Yang; Wang, Zhen; Li, Lianyun; Wu, Min

The EZH1-SUZ12 complex positively regulates the transcription of NF-κB target genes through interaction with UXT.

Su, Shuai-Kun; Li, Chun-Yuan; Lei, Pin-Ji; Wang, Xiang; Zhao, Quan-Yi; Cai, Yang; Wang, Zhen; Li, Lianyun; Wu, Min.

Affiliation

Su SK; Department of Biochemistry and Molecular Biology, College of Life Sciences, Hubei Provincial Key Laboratory of Developmentally Originated Disease, Wuhan University, Wuhan, Hubei 430072, China.
Li CY; Department of Biochemistry and Molecular Biology, College of Life Sciences, Hubei Provincial Key Laboratory of Developmentally Originated Disease, Wuhan University, Wuhan, Hubei 430072, China.
Lei PJ; Department of Biochemistry and Molecular Biology, College of Life Sciences, Hubei Provincial Key Laboratory of Developmentally Originated Disease, Wuhan University, Wuhan, Hubei 430072, China.
Wang X; Department of Biochemistry and Molecular Biology, College of Life Sciences, Hubei Provincial Key Laboratory of Developmentally Originated Disease, Wuhan University, Wuhan, Hubei 430072, China.
Zhao QY; Department of Biochemistry and Molecular Biology, College of Life Sciences, Hubei Provincial Key Laboratory of Developmentally Originated Disease, Wuhan University, Wuhan, Hubei 430072, China.
Cai Y; Department of Biochemistry and Molecular Biology, College of Life Sciences, Hubei Provincial Key Laboratory of Developmentally Originated Disease, Wuhan University, Wuhan, Hubei 430072, China.
Wang Z; Department of Biochemistry and Molecular Biology, College of Life Sciences, Hubei Provincial Key Laboratory of Developmentally Originated Disease, Wuhan University, Wuhan, Hubei 430072, China.
Li L; Department of Biochemistry and Molecular Biology, College of Life Sciences, Hubei Provincial Key Laboratory of Developmentally Originated Disease, Wuhan University, Wuhan, Hubei 430072, China wumin@whu.edu.cn lilianyun@whu.edu.cn.
Wu M; Department of Biochemistry and Molecular Biology, College of Life Sciences, Hubei Provincial Key Laboratory of Developmentally Originated Disease, Wuhan University, Wuhan, Hubei 430072, China wumin@whu.edu.cn lilianyun@whu.edu.cn.

J Cell Sci ; 129(12): 2343-53, 2016 06 15.

Article in En | MEDLINE | ID: mdl-27127229

Subject(s)

Gene Expression Regulation; NF-kappa B/metabolism; Neoplasm Proteins/metabolism; Polycomb Repressive Complex 2/metabolism; Transcription, Genetic; Apoptosis/drug effects; Cell Cycle Proteins; Cell Nucleus/drug effects; Cell Nucleus/metabolism; Gene Expression Regulation/drug effects; HCT116 Cells; Histones/metabolism; Humans; Lysine/metabolism; Methylation/drug effects; Molecular Chaperones; Protein Binding/drug effects; Protein Transport/drug effects; RNA Polymerase II/metabolism; Transcription Factor RelA/metabolism; Transcription Factors; Transcription, Genetic/drug effects; Tumor Necrosis Factor-alpha/pharmacology

Key words

EZH1; Histone methylation; NF-κB signaling pathway; Transcription regulation; UXT

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Transcription, Genetic / Gene Expression Regulation / NF-kappa B / Polycomb Repressive Complex 2 / Neoplasm Proteins Limits: Humans Language: En Journal: J Cell Sci Year: 2016 Type: Article Affiliation country: China

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