Paraneoplastic thrombocytosis in gastrointestinal cancer.
Platelets
; 27(4): 269-75, 2016 Jun.
Article
in En
| MEDLINE
| ID: mdl-27136385
ABSTRACT
It has been demonstrated recently in several solid tumors that thrombocytosis at diagnosis may correlate with tumor invasion, metastatic progression and worse outcome. Several details of the pathomechanism of the relationship of thrombocytosis and cancer have been elucidated; however, the complete process is not clearly understood. Several hypotheses have been proposed. Recently, it was suggested that in ovarian cancer elevated IL-6 production by the tumor may induce increased megakaryopoiesis via hepatic thrombopoietin production leading to thrombocytosis. The importance of the prognostic power of elevated platelet count is still debated in gastrointestinal cancer. The aims of this review were to evaluate the prognostic significance of thrombocytosis in gastrointestinal tumors, to see whether clinical practice confirmed the hypotheses and to reveal the causes of the inconsistent findings.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Paraneoplastic Syndromes
/
Thrombocytosis
/
Gastrointestinal Neoplasms
Type of study:
Diagnostic_studies
/
Prevalence_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Animals
/
Humans
Language:
En
Journal:
Platelets
Journal subject:
HEMATOLOGIA
Year:
2016
Type:
Article
Affiliation country:
Hungary